Skip to main content

Advertisement

Table 2 Independent correlates for mortality in elder patients with hip fracture—multivariate time-dependent Cox regression analysis*

From: Adherence to anti-osteoporosis medication associated with lower mortality following hip fracture in older adults: a nationwide propensity score-matched cohort study

  Univariate analysis Multivariate analysis
  HR (95% CI) p-value HR (95% CI) p-value
Osteoporotic drug usage status
 Without osteoporotic drug Reference group Reference group
 MPR < 80% 0.91 (0.818–1.011) 0.0804 0.835 (0.748–0.932) 0.0012
 MPR ≥ 80% 0.401 (0.32–0.503) <.0001 0.406 (0.322–0.511) <.0001
Age 1.062 (1.054–1.07) <.0001 1.064 (1.055–1.072) <.0001
Gender
 Male Reference group   Reference group  
 Female 0.746 (0.663–0.839) <.0001 0.776 (0.684–0.88) <.0001
Location
 North Reference group   Reference group  
 Middle 1.163 (1.025–1.321) 0.0192 1.066 (0.919–1.236) 0.4006
 Southern 0.979 (0.861–1.114) 0.7523 1.067 (0.926–1.23) 0.367
 East 1.169 (0.899–1.522) 0.2442 1.047 (0.778–1.408) 0.7639
Urbanization level
 Metropolitan areas Reference group   Reference group  
 Satellite cities or towns 1.146 (0.991–1.326) 0.0657 1.163 (1–1.352) 0.0498
 Rural areas 1.202 (1.067–1.355) 0.0026 1.204 (1.05–1.38) 0.0076
Charlson comorbidity index
 0 Reference group   Reference group  
 1 1.356 (1.134–1.622) 0.0009 1.266 (1.048–1.529) 0.0146
  ≥ 2 2.349 (2.018–2.733) <.0001 1.727 (1.429–2.086) <.0001
Comorbidity
 Diabetes 1.206 (1.084–1.342) 0.0006 1.242 (1.094–1.409) 0.0008
 Hypertension 1.008 (0.908–1.117) 0.8874 0.898 (0.803–1.004) 0.0591
 Cerebrovascular disease 1.308 (1.172–1.46) <.0001 1.063 (0.941–1.2) 0.3256
 Heart disease 1.246 (1.113–1.395) 0.0001 1 (0.886–1.128) 0.9996
 Cancer 3.621 (2.812–4.662) <.0001 2.521 (1.907–3.334) <.0001
 Chronic liver disease 1.22 (1.001–1.486) 0.0485 1.194 (0.968–1.471) 0.0978
 Chronic obstructive pulmonary disease 1.759 (1.568–1.975) <.0001 1.311 (1.151–1.493) <.0001
 Chronic kidney disease 1.891 (1.627–2.198) <.0001 1.787 (1.518–2.104) <.0001
 Hyperlipidemia 0.658 (0.556–0.778) <.0001 0.629 (0.524–0.755) <.0001
Type of hip fracture
 Neck Reference group   Reference group  
 Cervical 1.124 (0.944–1.339) 0.1896 1.098 (0.921–1.31) 0.2979
 Trochanteric 1.163 (1.041–1.3) 0.0075 1.04 (0.929–1.164) 0.5001
Prescribed by medical specialty
 Orthopedics Reference group   Reference group  
 Non-orthopedics 1.053 (0.948–1.169) 0.3387 0.96 (0.861–1.071) 0.4624
  1. HR hazards ratio; CI confidence interval
  2. *Stepwise model selection method was used for multivariate analysis