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Table 2 Published Literature on the Burden of Respiratory Syncytial Virus in Long-term Care Facilities

From: The burden of respiratory infections among older adults in long-term care: a systematic review

Author, Publication Year

Study Design

Country

Study Dates

Type of study

Age, Mean (SD)a, in years

n Infected / N at Riskb

Incidence Estimates

Sorvillo et al., 1984 [30]

Retrospective Cohort

United States

February–April 1979

Outbreak

79.2

13 / 101

12.9%

Ellis et al., 2003 [31]

Retrospective Cohort

United States

August 1, 1995 - July 31, 1999

Non-outbreak

Age ≥ 65, 100%

1105 infections / 88,851 person-yearsc

12.4 cases per 1000 person-years

McElhaney et al., 2004 [39]

Randomized Controlled Trial

United States

2000–2001d

Non-outbreak

82.2 (8.4)

3 / 198

1.5%

Caram et al., 2009 [18]

Prospective Cohort

United States

January 29, 2008 - February 26, 2008

Outbreak

70.8 (15.0)

7 / 52

13.5%

Johnstone et al., 2014 [17]

Prospective Cohort

Canada

2009, 2010, 2011e

Non-outbreak

Median 86 (IQR 80–90)

12 / 1072

1.1%

Uršič et al., 2016 [19]

Prospective Cohort

Slovenia

December 5, 2011 - May 31, 2012

Non-outbreak

Median 84 (IQR 79.8–88.8)

5 / 90

5.6%

Hui et al., 2008 [20]

Prospective Cohort

China

April 2006–March 2007

Non-outbreak

84.9 (8.9)

21 / 194

10.8%

  1. aIf available and unless another measure is specified
  2. bThe estimates and study participants’ characteristics were calculated among the unvaccinated individuals
  3. cOnly the number of person-years contributed by study sample was reported, not the number of individuals in the sample
  4. dThe published paper stated that study participants were enrolled in September or October and followed to the end of the respiratory viral season
  5. eParticipants were enrolled from mid-February through mid-March in 2000 for the first influenza season and trial. Then, a second trial was initiated in late December 2000 during a second influenza season, but the time period of enrollment was not reported