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Table 2 Published Literature on the Burden of Respiratory Syncytial Virus in Long-term Care Facilities

From: The burden of respiratory infections among older adults in long-term care: a systematic review

Author, Publication Year Study Design Country Study Dates Type of study Age, Mean (SD)a, in years n Infected / N at Riskb Incidence Estimates
Sorvillo et al., 1984 [30] Retrospective Cohort United States February–April 1979 Outbreak 79.2 13 / 101 12.9%
Ellis et al., 2003 [31] Retrospective Cohort United States August 1, 1995 - July 31, 1999 Non-outbreak Age ≥ 65, 100% 1105 infections / 88,851 person-yearsc 12.4 cases per 1000 person-years
McElhaney et al., 2004 [39] Randomized Controlled Trial United States 2000–2001d Non-outbreak 82.2 (8.4) 3 / 198 1.5%
Caram et al., 2009 [18] Prospective Cohort United States January 29, 2008 - February 26, 2008 Outbreak 70.8 (15.0) 7 / 52 13.5%
Johnstone et al., 2014 [17] Prospective Cohort Canada 2009, 2010, 2011e Non-outbreak Median 86 (IQR 80–90) 12 / 1072 1.1%
Uršič et al., 2016 [19] Prospective Cohort Slovenia December 5, 2011 - May 31, 2012 Non-outbreak Median 84 (IQR 79.8–88.8) 5 / 90 5.6%
Hui et al., 2008 [20] Prospective Cohort China April 2006–March 2007 Non-outbreak 84.9 (8.9) 21 / 194 10.8%
  1. aIf available and unless another measure is specified
  2. bThe estimates and study participants’ characteristics were calculated among the unvaccinated individuals
  3. cOnly the number of person-years contributed by study sample was reported, not the number of individuals in the sample
  4. dThe published paper stated that study participants were enrolled in September or October and followed to the end of the respiratory viral season
  5. eParticipants were enrolled from mid-February through mid-March in 2000 for the first influenza season and trial. Then, a second trial was initiated in late December 2000 during a second influenza season, but the time period of enrollment was not reported