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Table 4 Associations between CDR-SoB measured at baseline (Model 1) or longitudinally (Model 2) and CSDD mean scorea

From: The course of depressive symptoms with decline in cognitive function - a longitudinal study of older adults receiving in-home care at baseline

Covariates

Model 1

Model 2

Unadjusted models

Adjusted AIC-reduced modelb

Unadjusted models

Adjusted AIC-reduced modelc

Regr.coeff. (SE)

p-value

Regr.coeff. (SE)

p-value

Regr.coeff. (SE)

p-value

Regr.coeff. (SE)

p-value

Main variables

 Time

0.0006 (0.0006)

0.244

0.0007 (0.0005)

0.191

−0.0002 (0.0005)

0.690

−0.0003 (0.0004)

0.530

 CDR-SoB

0.03 (0.002)

< 0.001

0.01 (0.003)

< 0.001

0.03 (0.002)

< 0.001

0.01 (0.002)

< 0.001

 CDR-SoB*Time

−0.0005 (0.0001)

< 0.001

−0.0005 (0.0001)

< 0.001

− 0.0005 (0.00009)

< 0.001

−0.0003 (0.00008)

< 0.001

Socio-demographic information

 Women

0.04 (0.01)

0.006

0.03 (0.01)

0.027

0.04 (0.01)

0.002

0.03 (0.01)

0.009

 Age (years)

−0.004 (0.001)

< 0.001

−0.004 (0.001)

0.001

−0.005 (0.001)

< 0.001

− 0.002 (0.0009)

0.026

 Single

0.009 (0.01)

0.515

  

0.01 (0.01)

0.330

  

General physical health

 GMHR

  Very poor

0.08 (0.03)

0.003

  

0.08 (0.03)

0.002

0.07 (0.02)

0.001

  Poor

0.02 (0.02)

0.393

  

0.04 (0.02)

0.067

0.03 (0.02)

0.054

  Fair

0.008 (0.02)

0.635

  

0.0008 (0.02)

0.968

0.004 (0.02)

0.813

  Good – ref.

0

       

P-ADL

0.0006 (0.002)

0.791

  

−0.001 (0.002)

0.577

  

I-ADL

−0.003 (0.004)

0.501

−0.008 (0.004)

0.047

0.0005 (0.004)

0.899

  

Neuropsychiatric sub-syndrome score

 Agitation

0.02 (0.001)

< 0.001

0.008 (0.001)

< 0.001

0.02 (0.001)

< 0.001

0.01 (0.001)

< 0.001

 Psychosis

0.02 (0.003)

< 0.001

  

0.02 (0.003)

< 0.001

  

 Affective

0.02 (0.001)

< 0.001

0.02 (0.001)

< 0.001

0.03 (0.001)

< 0.001

0.02 (0.001)

< 0.001

Use of psychotropic medication

 Antipsychotics

0.004 (0.03)

0.891

  

−0.02 (0.03)

0.476

  

 Antidepressants

0.03 (0.02)

0.086

  

0.04 (0.02)

0.032

  

 Anxiolytics

0.009 (0.02)

0.674

  

0.03 (0.02)

0.113

  

 Sedatives

0.03 (0.01)

0.024

0.03 (0.01)

0.030

0.04 (0.01)

0.006

  

 Cognitive enhancers

0.05 (0.03)

0.079

  

0.01 (0.03)

0.588

  

NH resident beforeT3

    

−0.12 (0.03)

< 0.001

−0.07 (0.02)

0.001

  1. AIC Akaike’s Information Criterion, CDR-SoB Clinical Dementia Rating Scale with sum of boxes, CSDD Cornell Scale for Depression in Dementia, GMHR General Medical Health Rating Scale, P-ADL Personal functioning assessed with Lawton and Brody’s Physical Self-Maintenance Scale, I-ADL Instrumental functioning assessed with Instrumental Activities of Daily Living Scale, NH Nursing home. Bold p-values are significant
  2. aResults of linear mixed model
  3. After exclusion of cases with at least one missing value on covariates, in Model 1: N = 946 at T1, N = 505 at T2 and N = 412 at T3 and in Model-2: N = 946 at T1, N = 497 at T2 and N = 403 at T3. Random slope for time included
  4. bAdjusted for covariates measured at baseline
  5. cAdjusted for covariates measured simultaneously except for gender, age and living alone
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BMC Geriatrics

ISSN: 1471-2318

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