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Table 4 Associations between CDR-SoB measured at baseline (Model 1) or longitudinally (Model 2) and CSDD mean scorea

From: The course of depressive symptoms with decline in cognitive function - a longitudinal study of older adults receiving in-home care at baseline

Covariates Model 1 Model 2
Unadjusted models Adjusted AIC-reduced modelb Unadjusted models Adjusted AIC-reduced modelc
Regr.coeff. (SE) p-value Regr.coeff. (SE) p-value Regr.coeff. (SE) p-value Regr.coeff. (SE) p-value
Main variables
 Time 0.0006 (0.0006) 0.244 0.0007 (0.0005) 0.191 −0.0002 (0.0005) 0.690 −0.0003 (0.0004) 0.530
 CDR-SoB 0.03 (0.002) < 0.001 0.01 (0.003) < 0.001 0.03 (0.002) < 0.001 0.01 (0.002) < 0.001
 CDR-SoB*Time −0.0005 (0.0001) < 0.001 −0.0005 (0.0001) < 0.001 − 0.0005 (0.00009) < 0.001 −0.0003 (0.00008) < 0.001
Socio-demographic information
 Women 0.04 (0.01) 0.006 0.03 (0.01) 0.027 0.04 (0.01) 0.002 0.03 (0.01) 0.009
 Age (years) −0.004 (0.001) < 0.001 −0.004 (0.001) 0.001 −0.005 (0.001) < 0.001 − 0.002 (0.0009) 0.026
 Single 0.009 (0.01) 0.515    0.01 (0.01) 0.330   
General physical health
 GMHR
  Very poor 0.08 (0.03) 0.003    0.08 (0.03) 0.002 0.07 (0.02) 0.001
  Poor 0.02 (0.02) 0.393    0.04 (0.02) 0.067 0.03 (0.02) 0.054
  Fair 0.008 (0.02) 0.635    0.0008 (0.02) 0.968 0.004 (0.02) 0.813
  Good – ref. 0        
P-ADL 0.0006 (0.002) 0.791    −0.001 (0.002) 0.577   
I-ADL −0.003 (0.004) 0.501 −0.008 (0.004) 0.047 0.0005 (0.004) 0.899   
Neuropsychiatric sub-syndrome score
 Agitation 0.02 (0.001) < 0.001 0.008 (0.001) < 0.001 0.02 (0.001) < 0.001 0.01 (0.001) < 0.001
 Psychosis 0.02 (0.003) < 0.001    0.02 (0.003) < 0.001   
 Affective 0.02 (0.001) < 0.001 0.02 (0.001) < 0.001 0.03 (0.001) < 0.001 0.02 (0.001) < 0.001
Use of psychotropic medication
 Antipsychotics 0.004 (0.03) 0.891    −0.02 (0.03) 0.476   
 Antidepressants 0.03 (0.02) 0.086    0.04 (0.02) 0.032   
 Anxiolytics 0.009 (0.02) 0.674    0.03 (0.02) 0.113   
 Sedatives 0.03 (0.01) 0.024 0.03 (0.01) 0.030 0.04 (0.01) 0.006   
 Cognitive enhancers 0.05 (0.03) 0.079    0.01 (0.03) 0.588   
NH resident beforeT3      −0.12 (0.03) < 0.001 −0.07 (0.02) 0.001
  1. AIC Akaike’s Information Criterion, CDR-SoB Clinical Dementia Rating Scale with sum of boxes, CSDD Cornell Scale for Depression in Dementia, GMHR General Medical Health Rating Scale, P-ADL Personal functioning assessed with Lawton and Brody’s Physical Self-Maintenance Scale, I-ADL Instrumental functioning assessed with Instrumental Activities of Daily Living Scale, NH Nursing home. Bold p-values are significant
  2. aResults of linear mixed model
  3. After exclusion of cases with at least one missing value on covariates, in Model 1: N = 946 at T1, N = 505 at T2 and N = 412 at T3 and in Model-2: N = 946 at T1, N = 497 at T2 and N = 403 at T3. Random slope for time included
  4. bAdjusted for covariates measured at baseline
  5. cAdjusted for covariates measured simultaneously except for gender, age and living alone