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Table 2 Quantitative studies assessing treatment burden and the specific instruments or question used

From: A systematic literature review of the assessment of treatment burden experienced by patients and their caregivers

Reference Disease Instrument or question used to assess treatment burden
[65] Asthma Satisfaction with Inhaled Asthma Treatment Questionnaire
[35] Bronchiectasis Quality Of Life -B 3.0 questionnaire
[45] Cancer (breast) Quality of life questionnaire
[41] Cancer (Lung) Number of encounter days (inpatient or outpatient)
[40] Cancer (seminoma) Number of treatment episodes.
[34] Cancer, congestive heart failure or chronic obstructive pulmonary disease Willingness to Access life-Sustaining Treatment (WALT) instrument
[44] Celiac disease Participants asked to rate 4 domains on a scale of 0–100: difficulty in following treatment, perceived importance of following treatment, disease-specific health and overall health.
[52] Chronic conditions Living with Medicines Questionnaire V3 (LMQ-3)
[51] Chronic conditions Patient Experience with Treatment and Self-management (PETS)
[57] Diabetes
[7, 54] Chronic conditions Health Care Task Difficulty.
[47] Chronic conditions Treatment Burden Questionnaire (13-item)
[48] HIV
[11] Chronic conditions Treatment Burden Questionnaire (7-item)
[46, 49, 59] Chronic conditions Adapted Treatment Burden Questionnaire (15-item) to include financial burden question and side effects of medication question
[53] Chronic conditions Exercise Therapy Burden Questionnaire (ETBQ)
[50] Multimorbidity Multimorbidity Treatment Burden Questionnaire (MTBQ)
[38] Cystic Fibrosis As part of the CFQ-R, treatment burden was assessed with 3 questions.
[37] Diabetes Diabetes Treatment Burden Questionnaire (DTBQ)
[43] Lupus nephritis Likert scale rating of treatment burden.
[56] Medicare beneficiaries 4 questions about things patients are asked to do to stay healthy or treat health problems.
[36] Psoriasis Dermatology Life Quality Index
[42] Stroke Polypharmacy used as a measure of treatment burden
[39] Urinary Incontinence Patient Satisfaction Questionnaire
  1. CHQ: Child health questionnaire; CFQ-R: Cystic Fibrosis Questionnaire – Revised; TBQ: Treatment Burden Questionnaire; Diabetes Treatment Burden Questionnaire: DTBQ; Patient Experience with Treatment and Self-Management: PETS; Living with Medicines Questionnaire V3: LMQ-3; Medicine Regimen Complexity Index: MRCI; Exercise Therapy Burden Questionnaire: ETBQ; Multimorbidity Treatment Burden Questionnaire (MTBQ), Willingness to Access Life-Sustaining Treatment: WALT