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Table 3 The different outcomes and appropriate statistical method (partial list)

From: The effect of circuit resistance training, empagliflozin or “vegeterranean diet” on physical and metabolic function in older subjects with type 2 diabetes: a study protocol for a randomized control trial (CEV-65 trial)

  Endpoint type Statistical method
Primary outcome
 Change in body weight (%) from baseline to 10 weeks or to 20 weeks Continuous ANCOVA
 Change in % lean body mass from baseline to 10 weeks or to 20 weeks Continuous ANCOVA
 Proportion of participants having lost ≥2.5% at week 10 and 20 Binary Logistic regression
Secondary outcomes
 Change in waist circumference from baseline to 10 weeks or to 20 weeks Continuous ANCOVA
 Change in FPG and HB1Ac from baseline to 10 weeks or to 20 weeks Continuous ANCOVA
 Change in sarcopenia and frailty status (improved vs. not improved; change from one level to the other) at week 10 and 20 Binary Logistic regression
 Change in strength and other functional abilities from baseline to 10 weeks or to 20 weeks Continuous ANCOVA
 Change in systolic blood pressure from baseline to 10 weeks or to 20 weeks Continuous ANCOVA
 Change in quality of life (improved vs. not improved; change from one level to the other) at week 10 and 20 Binary Logistic regression
  1. Abbreviations: ANCOVA Analysis of Covariance, FPG Fasting Plasma Glucose, HbA1c Hemoglobin A1C