Table 3 The different outcomes and appropriate statistical method (partial list)
Endpoint type | Statistical method | |
|---|---|---|
Primary outcome | ||
Change in body weight (%) from baseline to 10 weeks or to 20 weeks | Continuous | ANCOVA |
Change in % lean body mass from baseline to 10 weeks or to 20 weeks | Continuous | ANCOVA |
Proportion of participants having lost ≥2.5% at week 10 and 20 | Binary | Logistic regression |
Secondary outcomes | ||
Change in waist circumference from baseline to 10 weeks or to 20 weeks | Continuous | ANCOVA |
Change in FPG and HB1Ac from baseline to 10 weeks or to 20 weeks | Continuous | ANCOVA |
Change in sarcopenia and frailty status (improved vs. not improved; change from one level to the other) at week 10 and 20 | Binary | Logistic regression |
Change in strength and other functional abilities from baseline to 10 weeks or to 20 weeks | Continuous | ANCOVA |
Change in systolic blood pressure from baseline to 10 weeks or to 20 weeks | Continuous | ANCOVA |
Change in quality of life (improved vs. not improved; change from one level to the other) at week 10 and 20 | Binary | Logistic regression |