Screening | Baseline day (W0–1)e | Familiarization of protocolb (W0–2) | After 1 week (W1) | After 6 weeks (W6) | After 10 weeksc (W10) | After 16 weeks (W16) | After 20 weeks (W20) | |
---|---|---|---|---|---|---|---|---|
On site visit number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Informed consent | X | |||||||
Eligibility criteria form | X | |||||||
Medical discharge and list of drugs from primary physician + physical activity confirmation letter | X | |||||||
Blood examinations from last 3 months (for eligibility) | X | |||||||
Physical examination for vital signs by study physician | X | X | X | |||||
Screening blood and urine tests (biochemistry and endocrinology): a) Urine microalbumin, sodium, creatinine, free cortisol) b) TSH, FT4 c) 25 OH vitamin D | X | |||||||
Demographic details, questions on health status, lifestyle using MABAT questionnaire | X | |||||||
Functional and physical activity questionnaires | X | |||||||
Food frequency questionnaire | X | |||||||
Guidance about diabetes diary | X | |||||||
Drug guidance for drug arm only | X | |||||||
Dietary guidance for diet arm only | X | X | X | X | ||||
CRT guidance for CRT arm only | X | X | ||||||
CRT guidance for drug and diet arms | X | |||||||
Height | X | |||||||
Body weight | X | X | X | |||||
Body circumferences | X | X | X | |||||
Body fat %, lean and muscle mass assessments using BIA method | X | X | X | |||||
Resting blood pressure | X | X | X | |||||
Resting energy expenditure | X | X | X | |||||
24 h blood pressure monitoring | X | X | X | |||||
Fasting plasma glucose and HbA1C | X | X | X | |||||
Testosterone (T) and bioavailable T | X | X | X | |||||
HOMA- Insulin X glucose/23.5 | X | X | X | |||||
LH, FSH, Estradiol | X | X | X | |||||
Diabetes diary (self-monitoring glucose levels, change in drugs) | X | X | X | |||||
Functional and frailty tests | X | X | X | |||||
CRT diary (report on training days and performance) | X | X | X | X | X | X | ||
Left of tablets count of drugs | X | X | ||||||
Adherence to MedD | X | X | X | |||||
Food diary – 3 days | X | X | X | |||||
Quality of life | X | X | X | |||||
Phone calls (adverse events monitoring) | X | X | X | X | X | X | ||
Encouragement using phone calls | X | X | X | X | X | X |