Development of model | Internal-external cross-validation | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Apparent performance (in 4 pooled cohorts) | Optimism-corrected performancea (in 4 pooled cohorts) | Development in ELSA, InCHIANTI, LASA | External validation in ActiFE-ULM | Development in ActiFE-ULM, InCHIANTI, LASA | External validation in ELSA | Development in ActiFE-ULM, ELSA, LASA | External validation in InCHIANTI | Development in ActiFE-ULM, ELSA, InCHIANTI | External validation in LASA | |
n = 2560 | n = 2560 | n = 2110 | n = 450 | n = 1424 | n = 1136 | n = 2090 | n = 470 | n = 2056 | n = 504 | |
Discrimination | ||||||||||
C statisticb | 0.719 (0.717–0.721) | 0.719 (0.716–0.720) | 0.721 (0.719–0.723) | 0.698 (0.695–0.700) | 0.738 (0.736–0.740) | 0.691 (0.687–0.694) | 0.713 (0.712–0.716) | 0.720 (0.718–0.723) | 0.711 (0.709–0.713) | 0.740 (0.738–0.742) |
Calibration | ||||||||||
Interceptc | 0.000 (0.000–0.000) | 0.059 (0.047–0.073) | 0.000 (0.000–0.000) | 0.135 (0.113--0.159) | 0.000 (0.000–0.000) | − 0.271 (− 0.293- -0.263) | 0.000 (0.000–0.000) | − 0.116 (− 0.144- -0.103) | 0.000 (0.000–0.000) | − 0.096 (− 0.112- -0.976) |
Slopec | 1.000 (1.000–1.000) | 1.053 (1.042–1.065) | 1.000 (1.000–1.000) | 0.949 (0.931–0.958) | 1.000 (1.000–1.000) | 0.757 (0.739–0.769) | 1.000 (1.000–1.000) | 0.966 (0.949–0.981) | 1.000 (1.000–1.000) | 1.215 (1.191–1.228) |