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Table 5 OR for use of each category of psychotropic drugs at one time-point given use of the same drug at the previous time point with covariates measured at the same previous time-point

From: Prevalence and persistent use of psychotropic drugs in older adults receiving domiciliary care at baseline

Variable

Antipsychotics (N = 954)

Antidepressants (N = 954)

Unadjusted

Adjusted

Unadjusted

Adjusted

OR (95% CI)

p-value

OR (95% CI)

p-value

OR (95% CI)

p-value

OR (95% CI)

p-value

Assessed at previous time-point

 CDR-SoB

1.14 (1.04; 1.24)

0.005

1.04 (0.91; 1.19)

0.5824

1.13 (1.07; 1.19)

< 0.001

1.04 (0.96; 1.13)

0.3465

 GMHR (Good/fairly good)

0.56 (0.26; 1.22)

0.145

1.08 (0.43; 2.73)

0.8669

0.91 (0.59; 1.40)

0.668

1.37 (0.84; 2.23)

0.2146

 PSMS

1.17 (1.07; 1.28)

0.001

1.13 (0.99; 1.29)

0.0572

1.13 (1.07; 1.20)

< 0.001

1.10 (1.01; 1.19)

0.025 3

 NPI Agitation sub-syndrome

1.07 (1.00; 1.14)

0.049

1.03 (0.94; 1.13)

0.5575

1.05 (1.00; 1.10)

0.037

0.97 (0.91; 1.02)

0.2488

 NPI Psychosis sub-syndrome

1.10 (0.97; 1.25)

0.148

0.98 (0.79; 1.22)

0.86710

1.12 (1.02; 1.23)

0.018

1.04 (0.93; 1.17)

0.48210

 NPI Affective sub-syndrome

1.03 (0.96; 1.09)

0.410

1.01 (0.92; 1.11)

0.8338

1.09 (1.05; 1.13)

< 0.001

1.08 (1.03; 1.13)

0.001 2

 Married

1.46 (0.64; 3.30)

0.365

0.84 (0.30; 2.39)

0.7487

0.69 (0.40; 1.20)

0.186

0.71 (0.38; 1.33)

0.2877

 Entry to NH

3.57 (1.11; 11.50)

0.033

1.67 (0.40; 7.01)

0.4886

3.54 (1.64; 7.68)

0.001

2.52 (1.02; 6.26)

0.047 4

Assessed at baseline

 Age

0.92 (0.86; 0.98)

0.016

0.91 (0.84; 0.99)

0.034 1

0.95 (0.91; 0.99)

0.021

0.93 (0.89; 0.97)

0.001 1

 Males

2.42 (1.12; 5.22)

0.025

2.10 (0.80; 5.53)

0.1333

0.68 (0.39; 1.16)

0.153

0.74 (0.40; 1.35)

0.3199

 

Anxiolytics (N = 954)

Sedatives (N = 954)

Unadjusted

Adjusted

Unadjusted

Adjusted

OR (95% CI)

p-value

OR (95% CI)

p-value

OR (95% CI)

p-value

OR (95% CI)

p-value

Assessed at previous time-point

 CDR-SoB

1.13 (1.06; 1.21)

< 0.001

1.05 (0.94; 1.17)

0.3774

1.05 (0.99; 1.11)

0.074

0.99 (0.92; 1.08)

0.8499

 GMHR (Good/fairly good)

0.80 (0.43; 1.51)

0.493

1.05 (0.51; 2.13)

0.9019

0.64 (0.41; 0.98)

0.039

0.70 (0.44; 1.12)

0.1373

 PSMS

1.15 (1.06; 1.24)

< 0.001

1.13 (1.01; 1.26)

0.031 2

1.09 (1.03; 1.16)

0.002

1.08 (0.99; 1.17)

0.0562

 NPI Agitation sub-syndrome

1.05 (0.99; 1.11)

0.089

0.98 (0.91; 1.06)

0.6658

1.02 (0.97; 1.07)

0.474

1.01 (0.95; 1.07)

0.81310

 NPI Psychosis sub-syndrome

1.13 (1.01; 1.27)

0.029

1.06 (0.92; 1.22)

0.4226

1.01 (0.91; 1.12)

0.892

0.96 (0.85; 1.10)

0.5767

 NPI Affective sub-syndrome

1.07 (1.02; 1.13)

0.003

1.04 (0.98; 1.10)

0.1673

1.03 (0.99; 1.07)

0.123

1.02 (0.98; 1.07)

0.3675

 Married

0.91 (0.43; 1.93)

0.801

1.52 (0.65; 3.59)

0.3375

0.77 (0.45; 1.32)

0.336

0.77 (0.43; 1.40)

0.3964

 Entry to NH

1.63 (0.50; 5.36)

0.420

0.67 (0.17; 2.60)

0.5617

1.29 (0.51; 3.23)

0.589

0.77 (0.28; 2.13)

0.6088

Assessed at baseline

 Age

1.02 (0.96; 1.09)

0.438

1.00 (0.94; 1.07)

0.97810

1.07 (1.02; 1.12)

0.003

1.07 (1.02; 1.12)

0.005 1

 Males

0.23 (0.08; 0.69)

0.009

0.18 (0.05; 0.61)

0.006 1

1.00 (0.61; 1.66)

0.988

1.17 (0.67; 2.06)

0.5856

  1. CDR-SoB Clinical Dementia Rating – Sum of Boxes
  2. GMHR General Medical Health Rating, PSMS Physical Self-Maintenance Scale, NPI Neuropsychiatric Inventory, NH Nursing Home