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Table 5 OR for use of each category of psychotropic drugs at one time-point given use of the same drug at the previous time point with covariates measured at the same previous time-point

From: Prevalence and persistent use of psychotropic drugs in older adults receiving domiciliary care at baseline

Variable Antipsychotics (N = 954) Antidepressants (N = 954)
Unadjusted Adjusted Unadjusted Adjusted
OR (95% CI) p-value OR (95% CI) p-value OR (95% CI) p-value OR (95% CI) p-value
Assessed at previous time-point
 CDR-SoB 1.14 (1.04; 1.24) 0.005 1.04 (0.91; 1.19) 0.5824 1.13 (1.07; 1.19) < 0.001 1.04 (0.96; 1.13) 0.3465
 GMHR (Good/fairly good) 0.56 (0.26; 1.22) 0.145 1.08 (0.43; 2.73) 0.8669 0.91 (0.59; 1.40) 0.668 1.37 (0.84; 2.23) 0.2146
 PSMS 1.17 (1.07; 1.28) 0.001 1.13 (0.99; 1.29) 0.0572 1.13 (1.07; 1.20) < 0.001 1.10 (1.01; 1.19) 0.025 3
 NPI Agitation sub-syndrome 1.07 (1.00; 1.14) 0.049 1.03 (0.94; 1.13) 0.5575 1.05 (1.00; 1.10) 0.037 0.97 (0.91; 1.02) 0.2488
 NPI Psychosis sub-syndrome 1.10 (0.97; 1.25) 0.148 0.98 (0.79; 1.22) 0.86710 1.12 (1.02; 1.23) 0.018 1.04 (0.93; 1.17) 0.48210
 NPI Affective sub-syndrome 1.03 (0.96; 1.09) 0.410 1.01 (0.92; 1.11) 0.8338 1.09 (1.05; 1.13) < 0.001 1.08 (1.03; 1.13) 0.001 2
 Married 1.46 (0.64; 3.30) 0.365 0.84 (0.30; 2.39) 0.7487 0.69 (0.40; 1.20) 0.186 0.71 (0.38; 1.33) 0.2877
 Entry to NH 3.57 (1.11; 11.50) 0.033 1.67 (0.40; 7.01) 0.4886 3.54 (1.64; 7.68) 0.001 2.52 (1.02; 6.26) 0.047 4
Assessed at baseline
 Age 0.92 (0.86; 0.98) 0.016 0.91 (0.84; 0.99) 0.034 1 0.95 (0.91; 0.99) 0.021 0.93 (0.89; 0.97) 0.001 1
 Males 2.42 (1.12; 5.22) 0.025 2.10 (0.80; 5.53) 0.1333 0.68 (0.39; 1.16) 0.153 0.74 (0.40; 1.35) 0.3199
  Anxiolytics (N = 954) Sedatives (N = 954)
Unadjusted Adjusted Unadjusted Adjusted
OR (95% CI) p-value OR (95% CI) p-value OR (95% CI) p-value OR (95% CI) p-value
Assessed at previous time-point
 CDR-SoB 1.13 (1.06; 1.21) < 0.001 1.05 (0.94; 1.17) 0.3774 1.05 (0.99; 1.11) 0.074 0.99 (0.92; 1.08) 0.8499
 GMHR (Good/fairly good) 0.80 (0.43; 1.51) 0.493 1.05 (0.51; 2.13) 0.9019 0.64 (0.41; 0.98) 0.039 0.70 (0.44; 1.12) 0.1373
 PSMS 1.15 (1.06; 1.24) < 0.001 1.13 (1.01; 1.26) 0.031 2 1.09 (1.03; 1.16) 0.002 1.08 (0.99; 1.17) 0.0562
 NPI Agitation sub-syndrome 1.05 (0.99; 1.11) 0.089 0.98 (0.91; 1.06) 0.6658 1.02 (0.97; 1.07) 0.474 1.01 (0.95; 1.07) 0.81310
 NPI Psychosis sub-syndrome 1.13 (1.01; 1.27) 0.029 1.06 (0.92; 1.22) 0.4226 1.01 (0.91; 1.12) 0.892 0.96 (0.85; 1.10) 0.5767
 NPI Affective sub-syndrome 1.07 (1.02; 1.13) 0.003 1.04 (0.98; 1.10) 0.1673 1.03 (0.99; 1.07) 0.123 1.02 (0.98; 1.07) 0.3675
 Married 0.91 (0.43; 1.93) 0.801 1.52 (0.65; 3.59) 0.3375 0.77 (0.45; 1.32) 0.336 0.77 (0.43; 1.40) 0.3964
 Entry to NH 1.63 (0.50; 5.36) 0.420 0.67 (0.17; 2.60) 0.5617 1.29 (0.51; 3.23) 0.589 0.77 (0.28; 2.13) 0.6088
Assessed at baseline
 Age 1.02 (0.96; 1.09) 0.438 1.00 (0.94; 1.07) 0.97810 1.07 (1.02; 1.12) 0.003 1.07 (1.02; 1.12) 0.005 1
 Males 0.23 (0.08; 0.69) 0.009 0.18 (0.05; 0.61) 0.006 1 1.00 (0.61; 1.66) 0.988 1.17 (0.67; 2.06) 0.5856
  1. CDR-SoB Clinical Dementia Rating – Sum of Boxes
  2. GMHR General Medical Health Rating, PSMS Physical Self-Maintenance Scale, NPI Neuropsychiatric Inventory, NH Nursing Home