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Table 4 OR for use of each category of psychotropic drugs at one time-point given use one or two time-points earlier, respectively, lag 1 and lag 2, covariates were measured at baseline

From: Prevalence and persistent use of psychotropic drugs in older adults receiving domiciliary care at baseline

Variable Number of users Unadjusted Adjustedb
Baseline A2 OR (95% CI) p-value OR (95% CI) p-valueo
Lag 1 (N=565a)
Antipsychoticsc 26 27 76.8 (28.5; 207.2) < 0.001 80.5 (28.9; 224.0) < 0.001
Antidepressantsd 97 118 53.3 (28.6; 90.1) < 0.001 47.3 (25.1; 89.1) < 0.001p
Anxiolyticse 44 67 25.9 (12.0; 55.5) < 0.001 23.6 (10.7; 52.1) < 0.001
Sedativesf 109 118 17.3 (10.5; 28.6) < 0.001 18.2 (10.9; 30.4) < 0.001
Lag 2 (N=432a)
  Baseline A3     
Antipsychoticsi 17 29 24.2 (7.1; 83.1) < 0.001 20.8 (5.8; 75.0) < 0.001
Antidepressantsj 66 97 29.8 (15.0; 59.2) < 0.001 28.1 (13.8; 57.4) < 0.001p
Anxiolyticsk 32 50 10.4 (4.5; 23.9) < 0.001 11.4 (4.5; 28.7) < 0.001
Sedativesl 74 98 6.6 (3.8; 11.3) < 0.001 6.6 (3.8; 11.4) < 0.001
  1. Lag 1: Two consecutive assessment time points (baseline and A2)
  2. Lag 2: One time point between selected time points (baseline and A3)
  3. a Cases with at least one missing on covariates were excluded
  4. bFollowing adjustment variables considered: Age, gender, marital status, CDR-SoB, GMHR, PSMS, NPI Affective sub-syndrome, NPI Psychosis sub-syndrome, NPI Agitation sub-syndrome all measured at A1 (baseline); Nursing home admission was not included as adjustment variable (no baseline values available); both models reduced by AIC
  5. cAdjusted for Gender
  6. dAdjusted for CDR-SoB and NPI Affective sub-syndrome
  7. eAdjusted for PSMS and NPI Affective sub-syndrome
  8. fAdjusted for NPI Affective sub-syndrome and NPI Agitation sub-syndrome
  9. gAdjusted for PSMS
  10. hAdjusted for CDR-SoB and NPI Psychosis sub-syndrome
  11. iAdjusted for Gender and PSMS
  12. jAdjusted for CDR-SoB, NPI Affective sub-syndrome and NPI Psychosis sub-syndrome
  13. kAdjusted for Marital status, GMHR and NPI Affective sub-syndrome
  14. lAdjusted for Age and CDR-SoB
  15. mAdjusted for Marital status and CDR-SoB
  16. nAdjusted for Gender, Age, Marital status and CDR-SoB
  17. op-values were calculated by generalized linear mixed model adjusting for municipality level if present
  18. p no cluster effect at municipality level present