Variable | Number of users | Unadjusted | Adjustedb |
---|
Baseline | A2 | OR (95% CI) | p-value | OR (95% CI) | p-valueo |
---|
Lag 1 (N=565a) |
Antipsychoticsc | 26 | 27 | 76.8 (28.5; 207.2) | < 0.001 | 80.5 (28.9; 224.0) | < 0.001 |
Antidepressantsd | 97 | 118 | 53.3 (28.6; 90.1) | < 0.001 | 47.3 (25.1; 89.1) | < 0.001p |
Anxiolyticse | 44 | 67 | 25.9 (12.0; 55.5) | < 0.001 | 23.6 (10.7; 52.1) | < 0.001 |
Sedativesf | 109 | 118 | 17.3 (10.5; 28.6) | < 0.001 | 18.2 (10.9; 30.4) | < 0.001 |
Lag 2 (N=432a) |
 | Baseline | A3 |  |  |  |  |
Antipsychoticsi | 17 | 29 | 24.2 (7.1; 83.1) | < 0.001 | 20.8 (5.8; 75.0) | < 0.001 |
Antidepressantsj | 66 | 97 | 29.8 (15.0; 59.2) | < 0.001 | 28.1 (13.8; 57.4) | < 0.001p |
Anxiolyticsk | 32 | 50 | 10.4 (4.5; 23.9) | < 0.001 | 11.4 (4.5; 28.7) | < 0.001 |
Sedativesl | 74 | 98 | 6.6 (3.8; 11.3) | < 0.001 | 6.6 (3.8; 11.4) | < 0.001 |
- Lag 1: Two consecutive assessment time points (baseline and A2)
- Lag 2: One time point between selected time points (baseline and A3)
- a Cases with at least one missing on covariates were excluded
- bFollowing adjustment variables considered: Age, gender, marital status, CDR-SoB, GMHR, PSMS, NPI Affective sub-syndrome, NPI Psychosis sub-syndrome, NPI Agitation sub-syndrome all measured at A1 (baseline); Nursing home admission was not included as adjustment variable (no baseline values available); both models reduced by AIC
- cAdjusted for Gender
- dAdjusted for CDR-SoB and NPI Affective sub-syndrome
- eAdjusted for PSMS and NPI Affective sub-syndrome
- fAdjusted for NPI Affective sub-syndrome and NPI Agitation sub-syndrome
- gAdjusted for PSMS
- hAdjusted for CDR-SoB and NPI Psychosis sub-syndrome
- iAdjusted for Gender and PSMS
- jAdjusted for CDR-SoB, NPI Affective sub-syndrome and NPI Psychosis sub-syndrome
- kAdjusted for Marital status, GMHR and NPI Affective sub-syndrome
- lAdjusted for Age and CDR-SoB
- mAdjusted for Marital status and CDR-SoB
- nAdjusted for Gender, Age, Marital status and CDR-SoB
- op-values were calculated by generalized linear mixed model adjusting for municipality level if present
- p no cluster effect at municipality level present