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Table 1 The clinical characteristics and laboratory data of the 99 adults with cryptococcal meningitis

From: The clinical characteristics and therapeutic outcomes of cryptococcal meningitis in elderly patients: a hospital-based study

  Non-elderly group (n = 61) Elderly group (n = 38) p-value
Gender
 Male 48 16 < 0.001
 Female 13 22  
Mortality at discharge 19 14 0.597
Underlying disease
 AIDS 11 1 0.026
 Diabetes mellitus 8 15 0.003
 Liver cirrhosis 6 3 1.000
 Hematologic disorders 7 5 1.000
 Autoimmune disorders 7 3 0.737
 Malignancy 3 6 0.083
 Chronic obstructive pulmonary disease 0 5 0.007
 Adrenal insufficiency 1 7 0.005
 Organ transplantation 1 0 1.000
 Immunocompromised state 26 17 0.837
Initial presentation    
 Headache 48 17 0.001
 Altered consciousness 20 29 < 0.001
 Fever 39 21 0.390
 Seizure 9 6 0.889
 Visual disturbance 15 1 0.004
 Hearing impairment 5 1 0.402
Cerebrospinal fluid data
White blood cell count (109/L) 0.17 0.09 0.022
 Glucose (mmol/L) 2.18 2.92 0.153
 Protein (g/L) 1.50 2.54 0.186
 Lactate (mmol/L) 5.25 5.35 0.896
 Positive India ink stain 22 9 0.113
 Cryptococcal Ag titer (≥1:1024) 26 12 0.163
 Positive culture result 51 26 0.004
Serum cryptococcal Ag titer (≥1:1024) 22 12 0.766
Cryptococcemia 21 9 0.258
Extraneural involvement 5 5 0.501
Neuroimaging findings
 Basal meningeal enhancement 22 12 0.584
 Pseudocyst/VR space dilatation 18 14 0.394
 Hydrocephalus 18 15 0.263
 Recent cerebral infarction 3 11 0.001
 Cryptococcoma 5 1 0.404
  1. AIDS acquired immunodeficiency syndrome, Ag antigen, VR Virchow-Robin