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Table 6 Prevalence of hyperkalaemia among subjects taking 1–4 drugs increasing serum potassium level (angiotensin-converting enzyme inhibitors + angiotensin II receptor blockers + aldosterone antagonists + potassium-sparing diuretics + potassium-containing agents)

From: Use of renal risk drugs in a nation-wide Polish older adult population: an analysis of PolSenior database

No. of drugs

CC

sMDRD

<  60 ml/min

≥ 60 ml/min

<  60 ml/min/1.73m2

≥ 60 ml/min/1.73m2

1; n (%) of subjects with hyperkalaemia

102/669 (15.26)* &

73/952 (7.67) &

73/391 (18.67)# &

102/1230 (8.29)

2; n (%) of subjects with hyperkalaemia

57/258 (22.09)*

22/248 (8.87)

52/180 (28.89)#

27/326 (8.28)

3; n (%) of subjects with hyperkalaemia

14/54 (25.93)

13/51 (25.49)

14/30 (46.67)#

13/75 (17.33)

4; n (%) of subjects with hyperkalaemia

1/1 (100)

0/33 (0)

1/1 (100)

0/3 (0)

  1. *p < 0.05 vs. patients with CC ≥ 60 ml/min
  2. #p < 0.05 vs. patients with sMDRD ≥60 ml/min/1.73m2
  3. &p < 0.05 for chi-square test for trend for number of drugs
  4. sMDRD short Modification of Diet in Renal Disease study equation; CC Creatinine clearance calculated with Cockcroft-Gault equation