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Table 4 Subjects taking drugs increasing risk of pre-renal impairment of kidney function (nonsteroidal anti-inflammatory drugs + angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers + diuretics)

From: Use of renal risk drugs in a nation-wide Polish older adult population: an analysis of PolSenior database

Drug combinations Total population (n = 4514) CC sMDRD
<  60 ml/min (n = 1734) ≥ 60 ml/min (n = 2780) <  60 ml/min/1.73m2 (n = 855) ≥ 60 ml/min/1.73m2 (n = 3659)
ACEI/ARB + diuretic; n (%) 840 (16.61) 391 (22.55)* 449 (16.15) 278 (32.51)# 562 (15.36)
ACEI/ARB + NSAID; n (%) 225 (4.56) 86 (4.59) 139 (5.00) 50 (5.85) 175 (4.78)
Diuretic + NSAID; n (%) 163 (3.61) 71 (4.09) 92 (3.31) 54 (6.32)# 109 (2.98)
ACEI/ARB + diuretic + NSAID; n (%) 98 (2.17) 39 (2.25) 59 (2.11) 31 (3.63)# 67 (1.83)
  1. *p < 0.05 vs. patients with CC ≥ 60 ml/min
  2. #p < 0.05 vs. patients with sMDRD ≥60 ml/min/1.73m2
  3. ACEI Angiotensin-converting enzyme inhibitor; sMDRD = short Modification of Diet in Renal Disease study equation; ARB = angiotensin II receptor blocker; CC = creatinine clearance; NSAID = nonsteroidal anti-inflammatory drug