Associations of the metabolic syndrome and its components with cognitive impairment in older adults

BMC Geriatrics

Table 4 MetS, each of the 5 MetS components and odds of cognitive impairment

	Model 1		Model 2		Model 3
	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
Metabolic syndrome	1.38 (0.74, 2.60)	0.310	–	–	1.25 (0.65, 2.42)	0.503
Obesity	1.07 (0.52, 2.23)	0.852	1.00 (0.46, 2.17)	0.997	1.08 (0.48, 2.43)	0.845
Elevated triglycerides	2.09 (1.08, 4.05)	0.028	2.23 (1.07, 4.65)	0.033	1.86 (0.87, 4.00)	0.110
Reduced high-density lipoprotein	1.19 (0.63, 2.23)	0.600	0.86 (0.42, 1.77)	0.691	0.87 (0.41, 1.82)	0.704
Elevated blood pressure	1.11 (0.60, 2.07)	0.740	1.04 (0.54, 2.00)	0.911	0.86 (0.44, 1.71)	0.668
Elevated glucose	1.12 (0.60, 2.08)	0.721	0.98 (0.51, 1.88)	0.948	1.09 (0.55, 2.14)	0.811

Results shown for logistic regression analyses for odds of cognitive impairment. CI, confidence interval; OR, odds ratio. For definitions of metabolic syndrome components, see Table 1. Model 1: separate models associated each exposure variable with cognitive impairment with adjustment for age, sex and smoking (N = 202). Model 2: single model including age, sex, smoking, obesity, elevated TG, reduced HDL-C, elevated blood pressure, elevated glucose (N = 202). Model 3: single model including age, sex, smoking, obesity, elevated TG, reduced HDL-C, elevated blood pressure, elevated glucose, CHD, TIA, stroke (N = 200). Model 3 is a separate model for MetS. Results largely unchanged following exclusion of N = 1 outlier with high TG levels (28.9 mmol/L)

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