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Table 2 Diagnostic value of visual rating scale for discriminating dementia of Alzheimer’s type from normal cognition

From: A new age-related cutoff of medial temporal atrophy scale on MRI improving the diagnostic accuracy of neurodegeneration due to Alzheimer’s disease in a Chinese population

Scales Criteria Age group Cutoffs AUC(95%CI) Sen(%) Spe(%) FNR(%) Youden index PPV(%) NPV(%)
MTAi   0.42 (0.32–0.52)
PA   0.46 (0.36–0.56)
GCA   Total 1 0.74 (0.65–0.82) 63.8 73.1 36.2 0.369 49.0 80.9
 50–64 1 0.69 (0.54–0.83) 53.8 77.9 46.2 0.317 48.4 80.0
 65–74 0.5 0.74 (0.59–0.88) 90.5 48.1 9.5 0.386 59.1 68.9
 75–84 1 0.69 (0.50–0.88) 79.2 53.8 20.8 0.33 59.7 69.2
MTA Tian et al’ s criteria Total 1.5 0.92 (0.89~0.96) 84.5 79.1 15.5 0.636 56.1 94.2
 50–64 1.0 0.88 (0.78~0.98) 92.3 68.4 7.7 0.607 36.1 96.7
 65–74 1.5 0.95 (0.89~1.00) 90.4 85.2 9.6 0.756 49.8 96.7
 75–84 2.0 0.75 (0.63~0.93) 70.8 82.3 29.2 0.538 42.1 90.3
Scheltens’ criteria Total    60.0 95.6 40.0 0.556 74.8 88.7
  ≤ 75 2.0   70.7 95.5 29.3 0.662 63.4 91.5
  > 75 3.0   40.7 74.6 59.3 0.153 25.1 80.5
  1. Notes: Sen Sensitivity, Spe Specificity, FNR False negative rate, PPV Positive predictive values, NPV Negative predictive value, AUC Area under curve, CI Confidence intervals
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