Table 1 Content of the Medication Review for LTC patients

Drug-drug interactions (DDI)

• DDI categorized potentially severe

• DDI categorized less severe but considered relevant, e.g. for the therapy’s effectiveness or due to additive adverse effects

Double medication

• Double administration of the same active drugs or drug class if not considered plausible

Inappropriate dosage interval

• Dosage interval not corresponding to the SPC if considered relevant, e.g. for the prevention of adverse drug effects

Inappropriate administration time

• Administration time not corresponding to the SPC if considered relevant, e.g. for the therapy’s effectiveness

Potentially inappropriate medication (PIM)

• Drug from the PRISCUS list [13] taking dose-dependence into account, and

• drug effect mainly systemic, and

• alternative drug available

Inappropriate dosage form

• Product that is divided but not divisible according to the SPC

Inappropriate dosage

• Dosage/strength not recommended for any indication or not age-adjusted according to the SPC and/or PRISCUS list

Inappropriate duration of use

• Duration of use not recommended according to the SPC

Indication to start a drug treatment

• Medication indicating the need for another drug, e.g. for the prevention of adverse drug effects

Contraindication comorbidity

• Drug not generally recommended due to a comorbidity that is obvious from the medication

Others

• e.g. use of a recalled product