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Table 2 Association between deprived and unequal neighborhood characteristics and risk of dementia, according to activity space

From: Influence of activity space on the association between neighborhood characteristics and dementia risk: results from the 3-City study cohort

Deprived and unequal neighborhood characteristics All-type dementia (n = 789) Univariate model Multivariate modela
n HR (95% IC) p HR (95% IC) p
3C deprivation score No limited activity space      
T1 (most privileged) 192 1 1
T2 202 0.97 (0.79–1.18) 0.73 0.97 (0.80–1.17) 0.74
T3 (most deprived) 218 1.06 (0.85–1.31) 0.62 1.04 (0.83–1.29) 0.76
Global p-value    0.64   0.80
Limited activity space      
T1 (most privileged) 47 1 1
T2 51 1.09 (0.73–1.63) 0.68 1.07 (0.72–1.60) 0.74
T3 (most deprived) 79 1.45 (1.01–2.06) 0.04 1.37 (0.92–2.05) 0.12
Global p-value    0.06   0.23
Proportion of blue collar workers No limited activity space      
T1 (< 13.6) 215 1 1
T2 (13.6–20.8) 186 0.98 (0.81–1.18) 0.81 0.90 (0.75–1.08) 0.24
T3 (> 20.8) 211 1.13 (0.93–1.38) 0.21 0.95 (0.78–1.15) 0.61
Global p-value    0.32   0.51
Limited activity space      
T1 (< 13.6) 50 1 1
T2 (13.6–20.8) 52 1.01 (0.71–1.44) 0.96 0.94 (0.65–1.35) 0.73
T3 (> 20.8) 75 1.38 (1.00–1.90) 0.05 1.19 (0.85–1.67) 0.32
Global p-value    0.09   0.37
Proportion of households without car No limited activity space      
T1 (< 21.2) 188 1 1
T2 (21.2–29.0) 221 1.17 (0.96–1.43) 0.13 1.20 (1.00–1.44) 0.05
T3 (> 29.0) 203 1.00 (0.81–1.24) 0.99 1.00 (0.83–1.22) 0.98
Global p-value    0.19   0.08
Limited activity space      
T1 (< 21.2) 44 1 1
T2 (21.2–29.0) 56 1.28 (0.86–1.90) 0.22 1.36 (0.92–2.01) 0.13
T3 (> 29.0) 77 1.48 (1.04–2.12) 0.03 1.42 (1.00–2.03) 0.05
Global p-value    0.09   0.14
Gini index No limited activity space      
T1 (< 0.31) 191 1 1
T2 (0.31–0.35) 214 1.05 (0.85–1.29) 0.64 1.09 (0.89–1.33) 0.42
T3 (> 0.35) 207 0.93 (0.75–1.15) 0.48 0.97 (0.78–1.20) 0.75
Global p-value    0.39   0.42
Limited activity space      
T1 (< 0.31) 48 1 1
T2 (0.31–0.35) 62 1.23 (0.82–1.84) 0.32 1.28 (0.86–1.89) 0.22
T3 (> 0.35) 67 1.45 (0.98–2.15) 0.06 1.60 (1.04–2.45) 0.03
Global p-value    0.16   0.10
  1. aMarginal Cox model adjusted for sex, study center, education level, income, occupational category, APOEε4 carrier status, diabetes, history of cardiovascular diseases, depressive symptoms and disability (IADL « budget, medication, phone »)
  2. Note: People with limited activity space = people who have need to help to go shopping, or if they are unable to move without being accompanied, or if people are confined at home or at their neighborhood