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Table 2 Association between deprived and unequal neighborhood characteristics and risk of dementia, according to activity space

From: Influence of activity space on the association between neighborhood characteristics and dementia risk: results from the 3-City study cohort

Deprived and unequal neighborhood characteristics

All-type dementia (n = 789)

Univariate model

Multivariate modela

n

HR (95% IC)

p

HR (95% IC)

p

3C deprivation score

No limited activity space

     

T1 (most privileged)

192

1

1

T2

202

0.97 (0.79–1.18)

0.73

0.97 (0.80–1.17)

0.74

T3 (most deprived)

218

1.06 (0.85–1.31)

0.62

1.04 (0.83–1.29)

0.76

Global p-value

  

0.64

 

0.80

Limited activity space

     

T1 (most privileged)

47

1

1

T2

51

1.09 (0.73–1.63)

0.68

1.07 (0.72–1.60)

0.74

T3 (most deprived)

79

1.45 (1.01–2.06)

0.04

1.37 (0.92–2.05)

0.12

Global p-value

  

0.06

 

0.23

Proportion of blue collar workers

No limited activity space

     

T1 (< 13.6)

215

1

1

T2 (13.6–20.8)

186

0.98 (0.81–1.18)

0.81

0.90 (0.75–1.08)

0.24

T3 (> 20.8)

211

1.13 (0.93–1.38)

0.21

0.95 (0.78–1.15)

0.61

Global p-value

  

0.32

 

0.51

Limited activity space

     

T1 (< 13.6)

50

1

1

T2 (13.6–20.8)

52

1.01 (0.71–1.44)

0.96

0.94 (0.65–1.35)

0.73

T3 (> 20.8)

75

1.38 (1.00–1.90)

0.05

1.19 (0.85–1.67)

0.32

Global p-value

  

0.09

 

0.37

Proportion of households without car

No limited activity space

     

T1 (< 21.2)

188

1

1

T2 (21.2–29.0)

221

1.17 (0.96–1.43)

0.13

1.20 (1.00–1.44)

0.05

T3 (> 29.0)

203

1.00 (0.81–1.24)

0.99

1.00 (0.83–1.22)

0.98

Global p-value

  

0.19

 

0.08

Limited activity space

     

T1 (< 21.2)

44

1

1

T2 (21.2–29.0)

56

1.28 (0.86–1.90)

0.22

1.36 (0.92–2.01)

0.13

T3 (> 29.0)

77

1.48 (1.04–2.12)

0.03

1.42 (1.00–2.03)

0.05

Global p-value

  

0.09

 

0.14

Gini index

No limited activity space

     

T1 (< 0.31)

191

1

1

T2 (0.31–0.35)

214

1.05 (0.85–1.29)

0.64

1.09 (0.89–1.33)

0.42

T3 (> 0.35)

207

0.93 (0.75–1.15)

0.48

0.97 (0.78–1.20)

0.75

Global p-value

  

0.39

 

0.42

Limited activity space

     

T1 (< 0.31)

48

1

1

T2 (0.31–0.35)

62

1.23 (0.82–1.84)

0.32

1.28 (0.86–1.89)

0.22

T3 (> 0.35)

67

1.45 (0.98–2.15)

0.06

1.60 (1.04–2.45)

0.03

Global p-value

  

0.16

 

0.10

  1. aMarginal Cox model adjusted for sex, study center, education level, income, occupational category, APOEε4 carrier status, diabetes, history of cardiovascular diseases, depressive symptoms and disability (IADL « budget, medication, phone »)
  2. Note: People with limited activity space = people who have need to help to go shopping, or if they are unable to move without being accompanied, or if people are confined at home or at their neighborhood