Table 3 The domains of interest in the EMIF-AD 90+ Study

Cognitive reserve

Level of education

Interview

Home

Home

Cognitive activity

Cognitive abilities questionnaire

Home

Home

Vascular comorbidity

Cholesterol level, hypertension, DM, stroke, AF

Blood collection

Hospital

WMIC

Medical history and medication use

Home

Home

Blood pressure

Hospital

CRF

Diagnostick/heart rate

Home

CRF

Ultrasound carotid artery

Hospital

CRF

Mood and sleep

Depressive symptoms

Geriatric Depression Scale

Home

Home

Sleep disorder

Berlin Questionnaire and MSQ

Home

Home

Accelerometer (sleep quality)

Home

N/A

Sensory system

Visual acuity

ETDRS chart

Hospital

N/A

Retinal thickness

OCT

Hospital

N/A

Auditory function

Digits-in-noise test

Home

N/A

Olfactory function

Sniffin sticks

Hospital

N/A

Physical performance and capacity

Physical performance

Grip strength

Home

CRF

Short Physical Performance Battery or 4-min walking test

Hospital

CRF

BIA (muscle mass)

Hospital

N/A

Physical activity

Accelerometer

Home

N/A

Genetics

APOEε4 and APOEε2

Blood collection

Hospital

WMIC

Hallmarks of ageing

Level of inflammation markers

Blood collection (i.a. PBMCs)

Hospital

WMIC

Level of senescence markers

Skin biopsy (senescence markers p16, p53 and telomere associated foci)

Hospital

N/A

Nutritional status

BIA

Hospital

N/A

Blood collection

Hospital

CRF

BMI

Hospital

CRF

MNA

Home

N/A

Markers of neurodegeneration

Aβ1–42 and tau in CSF and blood

CSF collection

Blood collection

Hospital

N/A

Amyloid PET scan

Amyloid PET scan

Hospital

WMIC

Brain atrophy

Brain MRI scan or brain CT scan

Hospital

CRF

WMH

Brain MRI scan or brain CT scan

Hospital

CRF

White matter integrity

Brain MRI scan

Hospital

N/A

Brain connectivity

Brain MRI scan

Hospital

CRF

MEG

Hospital

N/A