Table 1 Eligibility Criteria PICOS

Participants

Meet the diagnosis of National Institute of Neurological and Communication Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association (NINCDS/ADRDA) criteria or The Diagnostic and Statistical Manual of Mental Disorders (DSM).

Mild cognitive impairment or other types of non-AD dementia; familial AD initiated before 50 y old or related to other genetic diseases.

Interventions

Any type of psychosocial interventions or combination of psychosocial interventions and ChEIs.

Comparisons

ChEIs (positive control); usual care (normal control)

Outcomes

Primary outcomes: MMSE; Secondary outcomes: Compliance

Study design

Randomized controlled trials; sample size>10/arm.