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Table 2 Multivariate analysis investigating determinants of the patient, caregiver and overall scores on the QoL-AD

From: Factors associated with quality of life in patients with Alzheimer’s disease

Variables Patient score (n = 99) Caregiver score (n = 84) Overall score (n = 100)
QoL-AD scorea Multivariate analyseb QoL-AD scorea Multivariate analysec QoL-AD scorea Multivariate analysed
β ± SE (β) p   β ± SE (β) p   β ± SE (β) p
Depression **   ***   ***
 yes 33.3 ± 4.6 −2.56 ± 1.28   29.8 ± 3.8 −3.46 ± 1.09   32.1 ± 3.6 −3.26 ± 1.02  
 no 37.1 ± 5.0    33.7 ± 4.5    36.0 ± 4.1   
Polypharmacy *   **   **
 yes 35.0 ± 4.7 −1.80 ± 0.99   31.6 ± 4.5 −1.91 ± 0.92   33.9 ± 4.0 −1.85 ± 0.81  
 no 37.0 ± 5.2    33.7 ± 5.1    35.9 ± 4.4   
Anxiety (NPI) *     
 yes 35.4 ± 5.0 −1.70 ± 1.01        
 no 37.3 ± 4.9         
Carer burden    ***   
 yes     31.0 ± 4.8 −3.50 ± 0.91     
 no     35.3 ± 4.1      
  1. *p < 0.10; **p < 0.05; ***p < 0.001
  2. Polypharmacy: > 3 medications per day;
  3. NPI NeuroPsychiatric Inventory
  4. amean ± standard deviation
  5. bvariables included in the multivariate analysis were patient’s age, polypharmacy, use of psychotropic agents, symptomatic treatment for AD, depression (Cornell’s scale), preserved motor capacity (ADL) and anxiety (NPI)
  6. cvariables included in the multivariate analysis were polypharmacy, depression (Cornell’s scale), presence of home nurse, agitation/aggression (NPI), apathy (NPI), disinhibition (NPI), aberrant motor behaviour (NPI), irritability (NPI), sleep and nighttime behaviour change (NPI), appetite & eating change (NPI) preserved motor capacity (ADL), ability to do shopping (IADL), ability to use transport (IADL) and existence of caregiver burden
  7. dvariables included in the multivariate analysis were patient’s age, polypharmacy, use of psychotropic agents, symptomatic treatment for AD, depression (Cornell’s scale), agitation/aggression (NPI), anxiety (NPI), sleep and nighttime behaviour change (NPI), preserved motor capacity (ADL) and existence of caregiver burden