Variables | Patient score (n = 99) | Caregiver score (n = 84) | Overall score (n = 100) |
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QoL-AD scorea | Multivariate analyseb | QoL-AD scorea | Multivariate analysec | QoL-AD scorea | Multivariate analysed |
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β ± SE (β) | p | | β ± SE (β) | p | | β ± SE (β) | p |
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Depression | ** | | *** | | *** |
yes | 33.3 ± 4.6 | −2.56 ± 1.28 | | 29.8 ± 3.8 | −3.46 ± 1.09 | | 32.1 ± 3.6 | −3.26 ± 1.02 | |
no | 37.1 ± 5.0 | | | 33.7 ± 4.5 | | | 36.0 ± 4.1 | | |
Polypharmacy | * | | ** | | ** |
yes | 35.0 ± 4.7 | −1.80 ± 0.99 | | 31.6 ± 4.5 | −1.91 ± 0.92 | | 33.9 ± 4.0 | −1.85 ± 0.81 | |
no | 37.0 ± 5.2 | | | 33.7 ± 5.1 | | | 35.9 ± 4.4 | | |
Anxiety (NPI) | * | | | | |
yes | 35.4 ± 5.0 | −1.70 ± 1.01 | | | | | | | |
no | 37.3 ± 4.9 | | | | | | | | |
Carer burden | | | *** | | |
yes | | | | 31.0 ± 4.8 | −3.50 ± 0.91 | | | | |
no | | | | 35.3 ± 4.1 | | | | | |
- *p < 0.10; **p < 0.05; ***p < 0.001
- Polypharmacy: > 3 medications per day;
- NPI NeuroPsychiatric Inventory
- amean ± standard deviation
- bvariables included in the multivariate analysis were patient’s age, polypharmacy, use of psychotropic agents, symptomatic treatment for AD, depression (Cornell’s scale), preserved motor capacity (ADL) and anxiety (NPI)
- cvariables included in the multivariate analysis were polypharmacy, depression (Cornell’s scale), presence of home nurse, agitation/aggression (NPI), apathy (NPI), disinhibition (NPI), aberrant motor behaviour (NPI), irritability (NPI), sleep and nighttime behaviour change (NPI), appetite & eating change (NPI) preserved motor capacity (ADL), ability to do shopping (IADL), ability to use transport (IADL) and existence of caregiver burden
- dvariables included in the multivariate analysis were patient’s age, polypharmacy, use of psychotropic agents, symptomatic treatment for AD, depression (Cornell’s scale), agitation/aggression (NPI), anxiety (NPI), sleep and nighttime behaviour change (NPI), preserved motor capacity (ADL) and existence of caregiver burden