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Table 2 Multivariate analysis investigating determinants of the patient, caregiver and overall scores on the QoL-AD

From: Factors associated with quality of life in patients with Alzheimer’s disease

Variables

Patient score (n = 99)

Caregiver score (n = 84)

Overall score (n = 100)

QoL-AD scorea

Multivariate analyseb

QoL-AD scorea

Multivariate analysec

QoL-AD scorea

Multivariate analysed

β ± SE (β)

p

 

β ± SE (β)

p

 

β ± SE (β)

p

Depression

**

 

***

 

***

 yes

33.3 ± 4.6

−2.56 ± 1.28

 

29.8 ± 3.8

−3.46 ± 1.09

 

32.1 ± 3.6

−3.26 ± 1.02

 

 no

37.1 ± 5.0

  

33.7 ± 4.5

  

36.0 ± 4.1

  

Polypharmacy

*

 

**

 

**

 yes

35.0 ± 4.7

−1.80 ± 0.99

 

31.6 ± 4.5

−1.91 ± 0.92

 

33.9 ± 4.0

−1.85 ± 0.81

 

 no

37.0 ± 5.2

  

33.7 ± 5.1

  

35.9 ± 4.4

  

Anxiety (NPI)

*

    

 yes

35.4 ± 5.0

−1.70 ± 1.01

       

 no

37.3 ± 4.9

        

Carer burden

  

***

  

 yes

   

31.0 ± 4.8

−3.50 ± 0.91

    

 no

   

35.3 ± 4.1

     
  1. *p < 0.10; **p < 0.05; ***p < 0.001
  2. Polypharmacy: > 3 medications per day;
  3. NPI NeuroPsychiatric Inventory
  4. amean ± standard deviation
  5. bvariables included in the multivariate analysis were patient’s age, polypharmacy, use of psychotropic agents, symptomatic treatment for AD, depression (Cornell’s scale), preserved motor capacity (ADL) and anxiety (NPI)
  6. cvariables included in the multivariate analysis were polypharmacy, depression (Cornell’s scale), presence of home nurse, agitation/aggression (NPI), apathy (NPI), disinhibition (NPI), aberrant motor behaviour (NPI), irritability (NPI), sleep and nighttime behaviour change (NPI), appetite & eating change (NPI) preserved motor capacity (ADL), ability to do shopping (IADL), ability to use transport (IADL) and existence of caregiver burden
  7. dvariables included in the multivariate analysis were patient’s age, polypharmacy, use of psychotropic agents, symptomatic treatment for AD, depression (Cornell’s scale), agitation/aggression (NPI), anxiety (NPI), sleep and nighttime behaviour change (NPI), preserved motor capacity (ADL) and existence of caregiver burden