Identifying drug substances of screening tool for older persons’ appropriate prescriptions for Japanese

Nomura, Kaori; Kojima, Taro; Ishii, Shinya; Yonekawa, Takuto; Akishita, Masahiro; Akazawa, Manabu

doi:10.1186/s12877-018-0835-y

BMC Geriatrics

Table 3 Proposal for drug coding of “List of drugs to be prescribed with special caution” ¹⁾

From: Identifying drug substances of screening tool for older persons’ appropriate prescriptions for Japanese

Therapeutic category/JAN English name	Japan ²⁾	ATC³⁾
Nervous system: Overall antipsychotic drugs - Antipsychotic drugs
Aripiprazole Hydrate	1179045	N05AX12
Asenapine Maleate	1179056	N05AH05
Blonanserin	1179048	N05AX
Bromperidol	1179028	N05 AD06
Chlorpromazine Hydrochloride	1171001	N05AA01
Chlorpromazine Phenolphthalinate	1171005	N05AA01
Clocapramine Hydrochloride Hydrate	1179030	N05AX
Clozapine	1179049	N05AH02
Fluphenazine Maleate	1172009	N05AB02
Haloperidol	1179020	N05 AD01
Levomepromazine Maleate	1172014	N05AA02
Mosapramine Hydrochloride	1179035	N05AX10
Nemonapride	1179036	N05AL
Olanzapine	1179044	N05AH03
Oxypertine	1179011	N05AE01
Paliperidone	1179053	N05AX13
Perphenazine	1172006 1172007	N05AB03
Perphenazine Fendizoate	1172004	N05AB03
Perphenazine Maleate	1172013	N05AB03
Perospirone Hydrochloride Hydrate	1179043	N05AX
Pimozide	1179022	N05AG02
Pipamperone Hydrochloride	1179006	N05 AD05
Prochlorperazine Maleate	1172010	N05AB04
Propericiazine (Periciazine)	1172005	N05 AC01
Quetiapine Fumarate	1179042	N05AH04
Risperidone	1179038	N05AX08
Spiperone	1179015	N05 AD
Sulpiride	1179016 2329009	N05AL01
Sultopride Hydrochloride	1179032	N05AL02
Tiapride Hydrochloride	1190004	N05AL03
Timiperone	1179026	N05 AD
Zotepine	1179024	N05AX11
Combination (see Table 5)
Nervous system: Benzodiazepines
Alprazolam	1124023	N05BA12
Bromazepam	1124020	N05BA08
Brotizolam	1124009	N05CD09
Chlordiazepoxide	1124028	N05BA02
Clorazepate Dipotassium	1124015	N05BA05
Clotiazepam	1179012	N05BA21
Cloxazolam	1124014	N05BA22
Diazepam	1124017	N05BA01
Estazolam	1124001	N05CD04
Ethyl Loflazepate	1124029	N05BA18
Etizolam	1179025	N05BA19
Fludiazepam	1124019	N05BA17
Flunitrazepam	1124008	N05CD03
Flurazepam Hydrochloride	1124002	N05CD01
Flutazolam	1124024	N05BA
Flutoprazepam	1124027	N05BA
Haloxazolam	1124005	N05CD
Lorazepam	1124022	N05BA06
Lormetazepam	1124010	N05CD06
Medazepam	1124021	N05BA03
Mexazolam	1124025	N05BA
Nimetazepam	1124004	N05BA
Nitrazepam	1124003	N05CD02
Oxazolam	1124013	N05BA
Quazepam	1124030	N05CD10
Rilmazafone Hydrochloride Hydrate	1129006	N05CD
Tofisopam	1124026	N05BA23
Triazolam	1124007	N05CD05
Nervous system: Non-benzodiazepines
Eszopiclone	1129010	N05CF04
Zolpidem Tartrate	1129009	N05CF02
Zopiclone	1129007	N05CF01
Nervous system: Tricyclic antidepressants
Amitriptyline Hydrochloride	1179002	N06AA09
Amoxapine	1179001	N06AA17
Clomipramine Hydrochloride	1174002	N06AA04
Dosulepin Hydrochloride	1179027	N06AA16
Imipramine Hydrochloride	1174006	N06AA02
Lofepramine Hydrochloride	1174004	N06AA07
Nortriptyline Hydrochloride	1179004	N06AA10
Trimipramine Maleate	1174005	N06AA06
Nervous system: Selective serotonin reuptake inhibitor (SSRI)
Escitalopram Oxalate	1179054	N06AB10
Fluvoxamine Maleate	1179039	N06AB08
Paroxetine Hydrochloride Hydrate	1179041	N06AB05
Sertraline Hydrochloride	1179046	N06AB06
Nervous system: Antiparkinsonian drugs – Anticholinergic drugs
Biperiden Hydrochloride	1162001	N04AA02
Mazaticol Hydrochloride Hydrate	1169004	N04AA10
Piroheptine Hydrochloride	1169003	N04AA
Profenamine Hibenzate	1163002	N04AA05
Profenamine Hydrochloride	1163001	N04AA05
Promethazine Hydrochloride	4413002	R06AD02 D04AA10
Promethazine Hibenzate	4413002	R06AD02 D04AA10
Promethazine Methylenedisalicylate	4413002	R06AD02 D04AA10
Trihexyphenidyl Hydrochloride	1169001 1169002	N04AA01
Systemic hormonal preparations, excl. Sex hormones and insulins: Oral corticosteroids
Betamethasone	2454004	H02AB01
Cortisone Acetate	2452001	H02AB10
Dexamethasone	2454002	D07AB19 H02AB02
Hydrocortisone	2452002	H02AB09
Methylprednisolone	2456003	H02AB04
Prednisolone	2456001 2456002	H02AB06
Triamcinolone	2454003	H02AB08
Combination (see Table 5)
Blood and blood forming organs: Antithrombotic drugs
Acetylsalicylic acid (Aspirin)	1143001 3399007	N02BA01 B01AC06
Apixaban	3339004	B01AF02
Cilostazol	3399002	B01AC23
Clopidogrel Sulfate	3399008	B01AC04
Dabigatran Etexilate Methanesulfonate	3339001	B01AE07
Edoxaban Tosilate Hydrate	3339002	B01AF03
Prasugrel Hydrochloride	3399009	B01AC22
Rivaroxaban	3339003	B01AF01
Ticlopidine Hydrochloride	3399001	B01AC05
Ticagrelor	3399011	B01AC24
Warfarin potassium	3332001	B01AA03
Combination (see Table 5)
Cardiovascular system: Digitalis
Digoxin	2113003 2113004	C01AA05
Metildigoxin	2113005	C01AA08
Cardiovascular system: High-ceiling diuretics
Azosemide	2139008	C03CA
Bumetanide	2139004	C03CA02
Furosemide	2139005	C03CA01
Piretanide	2139007	C03CA03
Torasemide	2139009	C03CA04
Cardiovascular system: Potassium-sparing agents
Eplerenone	2149045	C03DA04
Spironolactone	2133001	C03DA01
Cardiovascular system: Beta blocking agents
Alprenolol Hydrochloride	2123002	C07AA01
Arotinolol Hydrochloride	2123014	C07AA
Bufetolol Hydrochloride	2123006	C07AA
Carteolol Hydrochloride	2123005 2149025	C07AA15 S01ED05
Nadolol	2123015	C07AA12
Nipradilol	2149021	C07AA S01ED
Pindolol	2123009 2149011	C07AA03
Propranolol Hydrochloride	2123008 2149014	C07AA05
Cardiovascular system: Alpha1 blocking agents
Bunazosin Hydrochloride	2149015	C02CA
Doxazosin Mesilate	2149026	C02CA04
Prazosin Hydrochloride	2149002	C02CA01
Terazosin Hydrochloride Hydrate	2149023	G04CA03
Urapidil	2149020	C02CA06
Respiratory system: H₁ receptor antagonists (1st generation)
Alimemazine Tartrate	4413003	R06AD01
Chlorpheniramine Maleate	4419001 4419003	R06AB04
Clemastine Fumarate	4419008	R06AA04
Cyproheptadine Hydrochloride Hydrate	4419005	R06AX02
D-chlorpheniramine Maleate	4419002	R06AB04
Diphenhidramine	4411001	R06AA02
Homochlorcyclizine Hydrochloride	4419006	R06AE
Hydroxyzine Hydrochloride	1179005	N05BB01
Hydroxyzine Pamoate	1179019	N05BB01
Promethazine Hibenzate (relisted)	4413002	R06AD02
Promethazine Hydrochloride (relisted)	4413002	R06AD02
Promethazine Methylenedisalicylate (relisted)	4413002	R06AD02
Combination (see Table 5)
Alimentary tract and metabolism: H₂ receptor antagonists
Cimetidine	2325001	A02BA01
Famotidine	2325003	A02BA03
Lafutidine	2325006	A02BA08
Nizatidine	2325005	A02BA04
Ranitidine Hydrochloride	2325002	A02BA02
Roxatidine Acetate Hydrochloride	2325004	A02BA06
Alimentary tract and metabolism: Antiemetic agents
Metoclopramide	2399004	A03FA01
Promethazine Hibenzate (relisted)	4413002	R06AD02 D04AA10
Promethazine Hydrochloride (relisted)	4413002	R06AD02 D04AA10
Promethazine Methylenedisalicylate (relisted)	4413002	R06AD02 D04AA10
Alimentary tract and metabolism: Drugs for constipation
Magnesium Oxide	2344002 2344009	A02AA02 A06AD02
Alimentary tract and metabolism: Biguanides
Buformin Hydrochloride	3962001	A10BA03
Metformin Hydrochloride	3962002	A10BA02
Combination (see Table 5)
Alimentary tract and metabolism: sulfonylureas
Acetohexamide	3961001	A10BB31
Chlorpropamide	3961004	A10BB02
Glibenclamide	3961003	A10BB01
Gliclazide	3961007	A10BB09
Glimepiride	3961008	A10BB12
Glyclopyramide	3961002	A10BB
Tolbutamide	3961006	A10BB03
Combination (see Table 5)
Alimentary tract and metabolism: Alpha glucosidase inhibitors
Acarbose	3969003	A10BF01
Miglitol	3969009	A10BF02
Voglibose	3969004	A10BF03
Combination (see Table 5)
Alimentary tract and metabolism: Thiazoridinediones
Pioglitazone Hydrochloride	3969007	A10BG03
Combination (see Table 5)
Alimentary tract and metabolism: Sodium-glucose co-transporter 2 (SGLT2) inhibitors
Canagliflozin Hydrate	3969022	A10BK02
Dapagliflozin Propylene Glycolate Hydrate	3969019	A10BK01
Empagliflozin	3969023	A10BK03
Ipragliflozin L-proline	3969018	A10BK
Luseogliflozin Hydrate	3969020	A10BK
Tofogliflozin Hydrate	3969021	A10BK
Urologicals: Muscarinic receptor antagonists
Fesoterodine Fumarate	2590015	G04BD11
Imidafenacin	2590013	G04BD
Oxybutynin Hydrochloride	2590005	G04BD04
Propiverine Hydrochloride	2590007	G04BD06
Solifenacin Succinate	2590011	G04BD08
Tolterodine Tartrate	2590012	G04BD07
Musculo-skeletal system: Non-steroidal antiinflammatory drugs (NSAIDs)
Acemetacin	1145003	M01AB11
Amfenac Sodium Hydrate	1147006	M01AB
Ampiroxicam	1149030	M01 AC
Acetylsalicylic acid (Aspirin) (relisted)	1143001 3399007	N92BA01 B01AC06
Bucolome	1149009	M01AX
Diclofenac Sodium	1147002	M01AB05 S01 BC03 M02AA15
Emorfazone	1148004	N02BG
Etodolac	1149032	M01AB08
Flufenamate Aluminum	1141004	M01AG03
Flurbiprofen	1149011	M01AE09 M02AA19
Ibuprofen	1149001	M01AE01
Indometacin	1145001 1145002	C01EB03 M01AB01 M02AA23
Indomethacin Farnesil	1145005	M01AB01
Lornoxicam	1149036	M01 AC05
Loxoprofen Sodium Hydrate	1149019	M01AE M02AA
Mefenamic Acid	1141005	M01AG01
Meloxicam	1149035	M01 AC06
Mofezolac	1149033	M01AX
Nabumetone	1149027	M01AX01
Naproxen	1149007	M01AE02
Oxaprozin	1149026	M01AE12
Piroxicam	1149017	M01 AC01 M02AA07 S01 BC06
Pranoprofen	1149010	S01 BC09
Proglumetacin Maleate	1145004	M01AB14
Sulindac	1149015	M01AB02
Tiaprofenic Acid	1149025	M01AE11
Tiaramide Hydrochloride	1148001	N02BG
Zaltoprofen	1149029	M01AE
Combination (See Table 5)

Japanese version available at http://www.jpn-geriat-soc.or.jp/tool/xls/list_03.xlsx or http://www.jpn-geriat-soc.or.jp/tool/pdf/list_02.pdf
ATC: Anatomical Therapeutic Chemical Classification System
JAN: Japanese Accepted Names for Pharmaceuticals
Japan: the first 7-digit numbers of the code of the Japanese drug price list
¹⁾Drugs that had been previously approved but do not currently being marketed are excluded. The list includes long-term oral use drugs as a general rule, except self-injection insulin, according to the guidelines (Japan Geriatric Society. Guidelines for Medical Treatment and its Safety in the elderly 2015 (In Japanese). Toyko, Medical View Co., Ltd. 2015)
²⁾A different base adduct may or may not require different codes in Japan; hydroxyzine (1179005 for hydrochloride, 1179019 for pamoate) or promethazines (4413002)
^3)ATC codes for topical use were excluded, e.g. A07EA Corticosteroids acting locally, D04AA Antihistamines for topical use; defined daily dose (DDD) are not available for most of those
⁴⁾The guidelines distinguish sulpiride and sultopride from other antipsychotic drugs
⁵⁾The guidelines distinguish acetyhlsalicylic acid (aspirine) from other antithrombotic drugs
⁶⁾The guidelines distinguish oxybutynin from other muscarinic receptor antagonists
⁷⁾The guidelines does not have metildigoxin (oral), however it is marketed and added to the Table 3 from molecular based perspectives

Back to article page

ISSN: 1471-2318

Contact us

Submission enquiries: bmcgeriatrics@biomedcentral.com
General enquiries: ORSupport@springernature.com