Table 4 Predictors of Possible Adverse effects of Medications
Characteristic | Unadjusted PR (95% CI) | P value | Adjusted PR (95% CI) | P value |
|---|---|---|---|---|
≥1 possible side effect due to medication once or more per week | ||||
Polypharmacy | 1.7 (1.2–2.3) | 0.002 | 1.2 (0.8–1.6) | 0.38 |
Protease inhibitor based regimen | 1.7 (1.1–2.4) | 0.01 | 1.6 (1.1–2.3) | 0.01 |
Frailty score | ||||
0–2 | 1 | 1 | ||
3–4 | 2.1 (1.0–4.5) | 0.05 | 2.1 (1.0–4.5) | 0.05 |
5–6 | 2.9 (1.4–6.2) | 0.005 | 2.9 (1.4–6.1) | 0.006 |
7 or more | 4.7 (2.3–9.8) | < 0.001 | 4.4 (2.1–9.4) | < 0.001 |
Moderate or severe distress of ≥1 medication side effect | ||||
Polypharmacy | 1.9 (1.3–2.8) | 0.002 | 1.1 (0.7–1.7) | 0.57 |
Frailty score | ||||
0–2 | 1 | |||
3–4 | 1.4 (0.5–3.6) | 0.54 | 1.3 (0.5–3.5) | 0.55 |
5–6 | 2.8 (1.1–6.9) | 0.03 | 2.7 (1.1–6.8) | 0.03 |
7 or more | 5.7 (2.4–13.6) | < 0.001 | 5.4 (2.2–13.4) | < 0.001 |
≥1 Fall in previous 12 months | ||||
Polypharmacy | 1.6 (0.9–2.9) | 0.09 | 1.0 (0.6–1.6) | 0.90 |
Protease inhibitor based regimen | 1.9 (1.0–3.6) | 0.06 | 1.9 (1.1–3.3) | 0.03 |
Frailty score | ||||
0–2 | 1 | 1 | ||
3–4 | 2.3 (0.5–10.0) | 0.29 | 2.3 (0.5–10.4) | 0.28 |
5–6 | 5.1 (1.2–21.3) | 0.02 | 5.2 (1.2–22.3) | 0.02 |
7 or more | 9.0 (2.2–36.6) | 0.002 | 7.8 (1.9–32.4) | 0.005 |
Cognitive status (using MMSEa) | ||||
Normal cognition | 1 | 1 | ||
Mild cognitive decline | 2.4 (1.2–4.6) | 0.009 | 2.0 (1.1–3.9) | 0.03 |
Moderate cognitive decline | 4.1 (2.4–6.8) | < 0.001 | 3.6 (2.2–5.9) | < 0.001 |
Severe cognitive decline | 1.4 (0.5–4.4) | 0.53 | 1.1 (0.4–3.4) | 0.87 |