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Table 3 Cox regression analyses for the 1-year composite endpoint (all-cause death or HF related rehospitalization)

From: Predictive biomarkers for death and rehospitalization in comorbid frail elderly heart failure patients

 

1-year composite endpoint

 

Univariate analysis

Multivariate analysis

 

HR

95%CI

p-value

HR

95%CI

p-value

Age

1.04

1.02–1.06

< 0.001

1.03

1.01–1.06

0.003

Female sex

1.28

0.96–1.70

0.09

1.64

1.20–2.23

0.002

NYHA

1.54

1.18–2.01

0.002

Diabetes

1.16

0.98–1.38

0.09

   

Charlson comorbidity index

1.15

1.08–1.22

< 0.001

1.10

1.03–1.18

0.008

Barthel index

0.99

0.98–0.99

< 0.001

Urea

1.01

1.01–1.01

< 0.001

1.01

1.00–1.01

< 0.001

Creatinine

1.00

1.00–1.01

0.3

Hb

0.90

0.82–0.98

0.01

Na

0.97

0.93–1.00

0.07

   

NT-proBNPa

1.43

1.25–1.65

< 0.001

1.18

1.00–1.38

0.04

ST2a

1.63

1.44–1.85

< 0.001

1.41

1.21–1.63

< 0.001

CA125a

1.32

1.15–1.52

< 0.001

Hs-TnIa

1.21

1.05–1.39

0.007

  1. aLog-transformed and per 1 SD
  2. CA125 cancer antigen 125, NT-proBNP N-terminal pro-brain natriuretic peptide, hs-TnI high-sensitivity troponin I, ST2 Interleukin-1 receptor-like 1