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Table 2 Potential savings of a reduction of the rate of decline in cognition as measured by MMSE in patients in the GERAS study with mild AD dementia

From: Potential cost savings to be made by slowing cognitive decline in mild Alzheimer’s disease dementia using a model derived from the UK GERAS observational study

MMSE score change (baseline to 18 months)

% change in costs

(95% CL)

ΔCosta

(95% CL)

Difference in cost reduction

Health care costs

  − 3.6

12.5%

(6.7%; 18.3%)

£361

(194; 529)

NA

  − 2.52 (30% reduction)

8.7%

(4.7%; 12.8%)

£251

(136; 370)

£110

  − 1.8 (50% reduction)

6.2%

(3.4%; 9.1%)

£179

(98; 263)

£182

Health care and social care costs

  − 3.6

13.1%

(4.4%; 22.0%)

£1318

(443; 2214)

NA

  − 2.52 (30% reduction)

9.2%

(3.1%; 15.4%)

£926

(312; 1549)

£392

  − 1.8 (50% reduction)

6.5%

(2.2%; 11.0%)

£654

(221; 1107)

£664

Total societal costs

  − 3.6

8.7%

(1.8%; 15.7%)

£2239

(463; 4041)

NA

  − 2.52 (30% reduction)

6.1%

(1.2%; 11.0%)

£1570

(309; 2831)

£669

  − 1.8 (50% reduction)

4.3%

(0.9%; 7.9%)

£1107

(232; 2033)

£1133

  1. MMSE Mini-Mental State Examination, AD Alzheimer’s disease, CL confidence limits, ΔCost change in cost, NA not applicable
  2. aBased on mean costs of £2890 for health care costs; £10,062 for health care and social care; and £25,740 for total societal costs
  3. An MMSE score change of −3.6 represents the least square mean cognitive decline (based on MMSE) observed in this population over 18 months [6]. Smaller reductions in MMSE score indicate less cognitive decline