From: Diabetic kidney disease in the elderly: prevalence and clinical correlates
All | < 65 years | 65–75 years | > 75 years | |
---|---|---|---|---|
n = 157,595 | n = 58,238 | n = 56,682 | n = 42,675 | |
Male sex | 89,290 (56.7%) | 35,941 (61.7%) | 32,469 (57.3%) | 20,880 (48.9%) |
Age (years) | 68 ± 11 | 57 ± 7 | 70 ± 3 | 80 ± 4 |
Known duration of diabetes (years) | 11 ± 9 | 8 ± 7 | 12 ± 9 | 15 ± 11 |
Serum creatinine (mg/dL) | 0.98 ± 0.54 | 0.88 ± 0.43 | 0.99 ± 0.54 | 1.10 ± 0.63 |
eGFR (mL/min/1.73m2) | 76 ± 21 | 89 ± 18 | 74 ± 18 | 62 ± 19 |
Retinopathy | 22,250 (14.1%) | 6998 (12.0%) | 8773 (15.5%) | 6479 (15.2%) |
BMI (Kg/m2) | 29.6 ± 5.3 | 30.4 ± 5.8 | 29.6 ± 5.1 | 28.4 ± 4.7 |
HbA1c (%) | 7.2 ± 1.3 | 7.3 ± 1.4 | 7.2 ± 1.2 | 7.2 ± 1.2 |
HbA1c | ||||
7.0–7.4% | 26,576 (17.1%) | 9002 (15.7%) | 10,057 (18.0%) | 7517 (17.9%) |
7.5–8.5% | 32,320 (20.8%) | 11,265 (19.7%) | 11,473 (20.5%) | 9582 (22.8%) |
> 8.5% | 20,993 (13.5%) | 9214 (16.1%) | 6401 (11.4%) | 5378 (12.8%) |
Total cholesterol (mg/dL) | 177 ± 39 | 181 ± 40 | 175 ± 37 | 176 ± 38 |
Triglycerides (mg/dL) | 137 ± 90 | 147 ± 108 | 133 ± 82 | 128 ± 69 |
HDL (mg/dL) | 50 ± 14 | 48 ± 14 | 50 ± 14 | 51 ± 15 |
LDL (mg/dL) | 101 ± 33 | 104 ± 34 | 99 ± 32 | 100 ± 33 |
Systolic BP (mmHg) | 137 ± 18 | 134 ± 18 | 139 ± 18 | 140 ± 19 |
Diastolic BP (mmHg) | 78 ± 9 | 79 ± 9 | 78 ± 9 | 76 ± 9 |
Smokers | 14,793 (16.7%) | 8865 (25.2%) | 4435 (14.1%) | 1493 (6.9%) |
Cardiovascular therapy | ||||
Lipid-lowering treatment | 90,690 (57.5%) | 31,402 (53.9%) | 35,490 (62.6%) | 23,798 (55.8%) |
Treatment with statins | 83,342 (52.9%) | 28,002 (48.1%) | 32,928 (58.1%) | 22,412 (52.5%) |
Treatment with fibrates | 4588 (2.9%) | 2285 (3.9%) | 1503 (2.7%) | 800 (1.9%) |
Antihypertensive treatment | 112,424 (71.3%) | 35,069 (60.2%) | 43,031 (75.9%) | 34,324 (80.4%) |
Treatment with ACE-Is/ARBs | 95,821 (60.8%) | 30,460 (52.3%) | 36,938 (65.2%) | 28,423 (66.6%) |
Aspirin | 35,284 (22.4%) | 9467 (16.3%) | 14,278 (25.2%) | 11,539 (27.0%) |
Antidiabetic therapy | ||||
Diet | 8229 (5.2%) | 3149 (5.4%) | 3086 (5.4%) | 1994 (4.7%) |
Oral antidiabetic drugs | 100,535 (63.8%) | 39,150 (67.2%) | 36,379 (64.2%) | 25,006 (58.6%) |
Oral antidiabetic drugs and insulin | 26,634 (16.9%) | 9460 (16.2%) | 9906 (17.5%) | 7268 (17.0%) |
Insulin | 22,197 (14.1%) | 6479 (11.1%) | 7311 (12.9%) | 8407 (19.7%) |
Q Score | 30 ± 8 | 30 ± 8 | 30 ± 8 | 29 ± 8 |
< 15 | 5935 (3.8%) | 2534 (4.4%) | 1808 (3.2%) | 1593 (3.7%) |
15–25 | 42,165 (26.8%) | 15,375 (26.4%) | 14,447 (25.5%) | 12,343 (28.9%) |
> 25 | 109,495 (69.5%) | 40,329 (69.2%) | 40,427 (71.3%) | 28,739 (67.3%) |