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Table 3 Adjusted cox regression model for the effect of the four core symptoms of delirium status on mortality, sequentially adjusted for clinically relevant covariates

From: Key components of the delirium syndrome and mortality: greater impact of acute change and disorganised thinking in a prospective cohort study

HR (95% CI) p-value.

 

None (unadjusted)

+Age

+ Gender

+ CCI

+ Waterlow

+ APACHE II

Delirium key core symptoms

 Acute onset (n = 583)

1.88

1.80

1.80

1.76

1.46

1.41

(1.45, 2.42)

(1.39, 2.33)

(1.39, 2.33)

(1.35, 2.29)

(1.11, 1.91)

(1.07, 1.86)

p < 0.001*

p < 0.001*

p < 0.001*

p < 0.001*

p = 0.007*

p = 0.016*

 Inattention (n = 576)

1.80

1.74

1.75

1.73

1.33

1.24

(1.40, 2.32)

(1.35, 2.25)

(1.36, 2.26)

(1.34, 2.24)

(1.01, 1.77)

(0.92, 1.67)

p < 0.001*

p < 0.001*

p < 0.001*

p < 0.001*

p = 0.044*

p = 0.152

 Disorganised thinking (n = 563)

2.06

1.97

2.01

1.94

1.52

1.42

(1.59, 2.67)

(1.51, 2.55)

(1.54, 2.54)

(1,48, 2.54)

(1.14, 2.04)

(1.05, 1.92)

p < 0.001*

p < 0.001*

p < 0.001*

p < 0.001*

p = 0.005*

p = 0.024*

 Altered level of consciousness (n = 588)

2.04

1.95

1.96

1.82

1.41

1.33

(1.58, 2.63)

(1.50, 2.52)

(1.51, 2.53)

(1.40, 2.37)

(1.06, 1.88)

(0.98, 1.79)

p < 0.001*

p < 0.001*

p < 0.001*

p < 0.001*

p = 0.018*

p = 0.063

  1. Cox proportional hazard regression analysis for survival estimates for the four key core symptoms of full syndromal delirium. Unadjusted model complete case = 610. The same sample was used for the sequentially adjusted Cox proportional hazards regression model (age, gender, CCI, Waterlow and APACHE II). APACHE II and CCI scores were split into quartiles for the purpose of the analysis. There was no evidence of interactions, these, therefore were no longer considered. Proportional hazard assumptions were met, confirmed by Schoenfeld residuals ≥0.05. Significance level set at < 0.05
  2. CAM Confusion Assessment Method, HR hazard ratios, CI confidence intervals, p significance level, N number of participants, * significant, CCI Charlson Comorbidity Index, APACHE II Acute Physiology and Chronic Health Evaluation II