Table 3 Findings from the animal research published in the past five years

Reference

Strain/Experimental manipulation

Behavioral findings

Cellular /neurochemical findings

Fukushima-Nakayama et al. 2017 [44]

C57BL/6 J mice/Normal (N) or solid (S) diet

Passive avoidance test (−) and Object location test (−) in S group

Hippocampal neurons, neurogenesis, neuronal activity (−), BDNF expression (−) in S group

Kubo et al. 2017 [48]

SAMP8 mice/Tooth loss soon after tooth eruption

Morris water maze (−)

Cell proliferation/cell survival in DG (−)

Synaptophysin expression in HIP (−)

Newborn cell differentiation in DG (X)

Avivi-Arber et al. 2016 [43]

7 strains of female mice/Molar extraction

Regional and voxel-wise volumes of cortical brain regions (−) and subcortical, sensorimotor, temporal limbic regions (+)

Takeda et al. 2016 [59]

C57BL/6 J mice/Molar extraction (E) and powder (P) or solid (S) diet

Step-through passive avoidance test (−) for E/S and E/P groups 16 weeks later

BDNF-related mRNA in HIP (−) for E/S and E/P groups 16 weeks later

Oue et al. 2016 [53]

APP transgenic mice/Molar extraction

Step-through passive avoidance test (X)

Amount of Aβ and number of pyramidal cells in HIP (X)

Kondo et al. 2016 [47]

SAMP8 mice/Molar extraction (E) or intact (I) and standard (S) or enriched (R) environment

Morris water maze (−) in E group

Proliferation and survival of newborn cells in DG (−) and BDNF levels in HIP (−) in E group

Kida et al. 2015 [46]

Tooth extraction (E) and zinc-deficient (ZD) or zinc-sufficient (ZS)

Spatial memory (−) in E/ZD group; recovered in E/ZS group

Astrocytic density in CA1 (+) in ZD group

Pang et al. 2015 [55]

KM mice/Molar extraction

Morris water maze (−)

Levels of NO and inducible nitric oxide synthase in HIP (+)

Ono et al. 2015 [52]

Stress condition (S), stress with voluntary chewing condition (SC), and control condition (C)

Open-Field Test and Elevated Plus Maze Test (+) in SC vs. S

Extracellular dopamine concentration in HIP (+) in SC vs. S

Su et al. 2014 [57]

CD1 mice/Molar extraction

Density and absorbance of doublecortin- and neuronal nuclear antigen-positive cells (−)

Okihara et al. 2014 [51]

C57BL/6 J mice/Chow diet (C) or liquid diet (L)

Passive avoidance test (−) in L vs. C

BDNF level (+), TrkB (−), and number of pyramidal neurons (−) in HIP in L vs. C

Utsugi et al. 2014 [60]

Hard (H) or soft (S) diet

Avoidance of butyric acid (−) in S vs. H group

Expression of Fos-ir cells at the Pr5 (+) and the density of BrdU-ir cells in SVZ and OB (+) in H vs. S group

Nose-Ishibashi et al. 2014 [50]

C57BL6/J mice/Post-weaning and Hard (H) or soft (S) diet

Home cage activity (−), open fielf test (+), prepulse inhibition (−), learning and memory tests (X) in S vs. H group

Cell proliferation, BDNF and Akt1 gene expression (−) in HIP in S vs. H group

Kawahata et al. 2014 [45]

SAMP8 mice/molar extraction (E) or intact (I)

open-field test (+), object-recognition test (−) and weight (−) in E vs. I group

Patten et al. 2013 [56]

Sprague-Dawley rats/Solid diet (S) or liquid diet (L)

Neuronal differentiation and survival (X), HPA-axis function (X), cell proliferation in HIP and hypothalamus (−) in L vs. S group

Niijima-Yaoita et al. 2013 [49]

Powdered (P) or standard (S) diet

Social interaction time (+)

Dopamine turnover (+) and D4 receptor expression (−) in frontal cortex in P vs. S group

Oue et al. 2013 [54]

Transgenic mice/molar extraction (E) or intact (I)

Passive avoidance test (−) in E vs. I group

Neuronal cell number in CA1/CA3 (−) and Aβ, Aβ40, and Aβ4 level (X) in E vs. I group

Akazawa et al. 2013 [42]

Hard (H) or normal (N) diet

Morris water maze (+) in H vs. N group

Expression of glutamate receptor 1 mRNA (+) in DG in H vs. N group