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Table 3 Predictors of Type of Bladder Antimuscarinics Initiation in All New Users (n = 12,251)

From: An investigation of factors predicting the type of bladder antimuscarinics initiated in Medicare nursing homes residents

 

New non-selective ER user vs. new non-selective IR user

New selective user vs. New non-selective IR user

OR (95% CI)

OR (95% CI)

Age Group

 65 to 74

Ref.

Ref.

 75 to 84

1.044 (0.919–1.186)

0.982 (0.826–1.167)

 85 and Older

0.857 (0.752–0.977)a

0.888 (0.743–1.060)

Female

1.266 (1.130–1.418)a

1.321 (1.132–1.541)a

Race

 White

Ref.

Ref.

 Black

1.288 (1.089–1.523)a

0.894 (0.703–1.137)

 Other Race

1.062 (0.818–1.380)

1.353 (0.952–1.923)

Nursing Home Region

 Midwest

Ref.

Ref.

 Northeast

0.624 (0.557–0.700)a

0.562 (0.476–0.664)a

 South

0.647 (0.581–0.719)a

1.052 (0.917–1.207)

 West

0.848 (0.708–1.016)

0.622 (0.474–0.815)a

Body Mass Index

 Underweight

0.779 (0.663–0.916)a

0.673 (0.527–0.859)a

 Normal

Ref.

Ref.

 Overweight

1.080 (0.971–1.202)

1.181 (1.024–1.362)a

 Obese

1.346 (1.196–1.515)a

1.319 (1.124–1.547)a

Cognitive Performance Score

 Intact

Ref.

Ref.

 Borderline intact/Mild Impairment

1.009 (0.895–1.137)

1.057 (0.900–1.240)

 Moderate impairment

1.011 (0.886–1.154)

0.937 (0.783–1.120)

 Moderate-severe/Severe/Very Severe impairment

0.549 (0.456–0.659)a

0.512 (0.391–0.669)a

CHESS

 Score of 0

Ref.

Ref.

 Score of 1 or 2

0.940 (0.849–1.040)

0.853 (0.745–0.977)a

 Score of 3

0.727 (0.612–0.864)a

0.837 (0.663–1.057)

 Score of 4 or 5

0.685 (0.498–0.943)a

0.835 (0.538–1.295)

Activities of Daily Living

0.989 (0.980–0.997)a

0.976 (0.965–0.988)a

Elixhauser/Other Comorbidities

 Aphasia

0.554 (0.411–0.746)a

0.616 (0.399–0.951)a

 Congestive Heart Failure

0.831 (0.745–0.927)a

0.834 (0.716–0.971)a

 Hypertension, Uncomplicated

1.282 (1.170–1.406)a

1.037 (0.915–1.176)

 Weight Loss

0.777 (0.652–0.926)a

0.772 (0.596–0.999)a

Bladder Continence

 Continent

Ref.

Ref.

 Usually Continent

1.235 (1.064–1.433)a

1.076 (0.880–1.316)

 Occasionally Incontinent

1.575 (1.355–1.830)a

1.495 (1.224–1.827)a

 Frequently Incontinent

1.524 (1.326–1.751)a

1.503 (1.246–1.813)a

 Incontinent

1.083 (0.909–1.290)

1.204 (0.936–1.550)

No Bladder Continence Appliance or Program

1.217 (1.081–1.371)a

0.982 (0.836–1.153)

Bowel Continence

 Continent

Ref.

Ref.

 Usually Continent

0.741 (0.632–0.869)a

0.936 (0.763–1.150)

 Occasionally Incontinent

0.938 (0.775–1.135)

0.802 (0.617–1.042)

 Frequently Incontinent

0.759 (0.641–0.899)a

0.626 (0.493–0.795)a

 Incontinent

0.688 (0.573–0.826)a

0.582 (0.446–0.758)a

Urinary Tract Infection in Last 30 Days

1.119 (1.006–1.244)a

1.197 (1.037–1.382)a

Gait

 Unsteady Gait

1.140 (1.042–1.246)a

1.017 (0.900–1.148)

 Fell in Past 30 days

1.193 (1.082–1.315)a

1.072 (0.939–1.223)

 Hip Fracture in Last 180 Days

1.254 (1.047–1.502)a

1.025 (0.778–1.333)

 Other Fracture in Last 180 Days

1.249 (1.060–1.472)a

1.344 (1.071–1.662)a

Balance While Sitting

 Maintained position as required in test

Ref.

Ref.

 Unsteady, but able to rebalance self without physical support

1.043 (0.911–1.193)

0.958 (0.796–1.152)

 Partial physical support during test or stands but does not follow directions for test

1.026 (0.896–1.174)

0.866 (0.715–1.049)

 Not able to attempt test without physical help

0.883 (0.709–0.980)a

0.700 (0.551–0.890)a

Concomitant Medications

 Calcium Channel Blockers

1.014 (0.919–1.120)

1.182 (1.036–1.349)a

 Cognitive Enhancers

1.031 (0.929–1.144)

1.203 (1.047–1.382)a

 Antiparkinson

0.896 (0.774–1.038)

1.372 (1.139–1.653)a

 Antipsychotics

0.476 (0.425–0.532)a

0.874 (0.751–1.017)

 Antivertigo

0.269 (0.236–0.307)a

0.727 (0.608–0.869)a

 Anxiolytic Sedative or Hypnotic Agent

0.672 (0.591–0.763)a

1.015 (0.853–1.208)

 Antidepressant

0.597 (0.543–0.656)a

1.315 (1.157–1.494)a

 ARB

1.024 (0.889–1.180)

1.287 (1.077–1.538)a

 Alpha Blockers

1.024 (0.894–1.173)

1.299 (1.088–1.553)a

 Anticonvulsant

0.719 (0.646–0.799)a

0.935 (0.812–1.076)

 Vasodilators

0.595 (0.523–0.676)a

1.024 (0.861–1.216)

 Benzodiazepines

2.249 (1.357–3.727)a

1.694 (0.860–3.338)

Anticholinergic Burden Score

1.476 (1.443–1.510)a

0.808 (0.780–0.836)a

  1. aIndicates statistical significance