From: Achieved systolic blood pressure in older people: a systematic review and meta-analysis
Study name (year) | FU (months) | SBPTa study | P-h/sa of RCTs analysis | N participants | Antihypertensive | Age (SD) | Women (%) | Hypertension (%) | Diabetes (%) | Smoking (%) | Previous coronary disease (%) | Previous cerebrovascular disease (%) | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Intervention | Control | Intervention | Control | |||||||||||
140 to < 150 mmHg | ||||||||||||||
 HOT [14] (2000) | 45 | No | Yes | nd | nd | Thiazide, BB, CCB or ACEi | Thiazide, BB, CCB or ACEi | 70.6 (3.9) | 54 | 100 | 10 | 11 | 13 | |
130 to < 140 versus ≥ 140 mmHg | ||||||||||||||
 EWPHE [30] (1989) | 9 | Yes | Yes | 120 | 126 | thiazide + triamterene | thiazide + triamterene | 71.4 (6.9) | 70 | 100 | nd | 19 | 35 | |
 JATOS [10] (2008) | 24 | Yes | No | 2212 | 2206 | CCB | CCB | 73.6 (5.2) | 61 | 100 | 11 | 13 | 3 | 4 |
 VALISH [11] (2010) | 33 | Yes | No | 1545 | 1534 | ARB | ARB | 76.1 (4.1) | 62 | 100 | 13 | 19 | 5 | 6 |
 ADVANCE [28] (2010) 65–74 yo | 51 | No | Yes | 2845 | 2760 | Thiazide + ACEi | Placebo + usual antiHTN drug treatmentc | 68 (nd) | 42 | 61 | 100 | 10 | 11 | 8 |
 ADVANCE [28] (2010) ≥ 75 yo | 51 | No | Yes | 490 | 518 | Thiazide + ACEi | Placebo + usual antiHTN drug treatmentc | 77 (nd) | 40 | 67 | 100 | 6 | 16 | 12 |
 FEVER [21] (2011) | 40 | Yes | Yes | 1631 | 1548 | Thiazide + CCB | Thiazide + Placebo | > 65 | 61b | 100 | 12b | 29b | 2b | 10b |
 Wei et al. [24] (2013) | 48 | Yes | No | 363 | 361 | Thiazide, ACEi, BB or CCB | Thiazide, ACEi, BB or CCB | 76.5 (4.5) | 33 | 100 | 23 | 24 | nd | 6 |
 INVEST [27] (2014) | 24 | Yes | Yes | 4787 | 1747 | CCB/ACEi or BB/thiazide | CCB/ACEi or BB/thiazide | 70.7 (7.3) | 55 | 100 | 29 | 42 | 100 | 8 |
< 130 versus ≥ 130 mmHg | ||||||||||||||
 LIFE [22] (2012) | 55 | Yes | Yes | 5704e | ARB or BB | ARB or BB | ≥ 65 | 54b | 100 | 13b | 16b | 16b | 4b | |
 SPS3 [12] (2015) | 42 | Yes | Yes | 248 | 246 | Any | Any | 79.9 (3.8) | 45 | 77 | 27 | 5 | 10 | 100 |
37 | Yes | Nod | 1317 | 1319 | Any | Any | 79.8 (4) | 38 | nd | 0 | 13b | 24,5 | 0 |