Table 5 Three leading causes of death within each selected major cause of death, based on ICD-10 chapters
ICD categories | Underlying causes of death among individuals with DS (n = 761) | Underlying causes of death among individuals with ID (DS excluded) (n = 3977) | Underlying causes of death among matched samples from the control population (n = 8364) |
|---|---|---|---|
Ch. IX – Diseases of the circulatory system (I00-I99) | n = 122 | n = 1368 | n = 2959 |
I50 Heart failure (25.4%) | I21 Acute myocardial infarction (23.3%) | I21 Acute myocardial infarction (24.1%) | |
I21 Acute myocardial infarction (14.8%) | I25 Chronic ischaemic heart disease (16.6%) | I25 Chronic ischaemic heart disease (21.3%) | |
I25 Chronic ischaemic heart disease (12.3%) | I50 Heart failure (11.8%) | I50 Heart failure (7.7%) | |
Ch. X – Diseases of the respiratory system (J00-J99) | n = 51 | n = 468 | n = 530 |
J69 Pneumonitis due to solids and liquids (31.4%) | J18 Pneumonia, organism unspecified (50.0%) | J44 Other chronic obstructive pulmonary disease (48.9%) | |
J18 Pneumonia, organism unspecified (19.6%) | J44 Other chronic obstructive pulmonary disease (19.9%) | J18 Pneumonia, organism unspecified (24.5%) | |
J45 Asthma (7.8%) | J69 Pneumonitis due to solids and liquids (10.0%) | J84 Other interstitial pulmonary diseases (8.7%) | |
J20 Acute bronchitis (7.8%) | |||
J98 Other respiratory disorders (7.8%) | |||
Ch. II – Neoplasms in men (C00-D48) | n = 9 | n = 381 | n = 1555 |
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs (33.3%) | C18 Malignant neoplasm of colon (12.9%) | C34 Malignant neoplasm of bronchus and lung (18.3%) | |
C25 Malignant neoplasm of pancreas (11.1%) | C61 Malignant neoplasm of prostate (10.5%) | C61 Malignant neoplasm of prostate (16.5%) | |
C67 Malignant neoplasm of bladder (11.1%) | C34 Malignant neoplasm of bronchus and lung (7.1%) | C25 Malignant neoplasm of pancreas (6.8%) | |
C16 Malignant neoplasm of stomach (11.1%) | |||
C90 Multiple myeloma and malignant plasma cell neoplasms (11.1%) | |||
C76 Malignant neoplasm of other and ill-defined sites (11.1%) | |||
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx (11.1%) | |||
Ch. II – Neoplasms in women (C00-D48) | n = 6 | n = 313 | n = 1194 |
C67 Malignant neoplasm of bladder (16.7%) | C50 Malignant neoplasm of breast (13.4%) | C34 Malignant neoplasm of bronchus and lung (19.9%) | |
C24 Malignant neoplasm of other and unspecified parts of biliary tract (16.7%) | C18 Malignant neoplasm of colon (9.3%) | C50 Malignant neoplasm of breast (13.0%) | |
C26 Malignant neoplasm of other and ill-defined digestive organs (16.7%) | C34 Malignant neoplasm of bronchus and lung (8.6%) | C25 Malignant neoplasm of pancreas (8.0%) | |
C22 Malignant neoplasm of liver and intrahepatic bile ducts (16.7%) | |||
C57 Malignant neoplasm of other and unspecified female genital organs (16.7%) | |||
C76 Malignant neoplasm of other and ill-defined sites (16.7%) | |||
Ch. VI – Diseases of the nervous system (G00-G99) | n = 35 | n = 218 | n = 325 |
G30 Alzheimer disease (54.3%) | G40 Epilepsy (21.6%) | G30 Alzheimer disease (44.0%) | |
G40 Epilepsy (37.1%) | G80 Cerebral palsy (19.3%) | G20 Parkinson disease (15.7%) | |
G31 Other degenerative diseases of nervous system, not elsewhere classified (5.7%) | G30 Alzheimer disease (10.1%) | G12 Spinal muscular atrophy and related syndromes (12.0%) |