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Table 5 Three leading causes of death within each selected major cause of death, based on ICD-10 chapters

From: Mortality patterns and risk among older men and women with intellectual disability: a Swedish national retrospective cohort study

ICD categories Underlying causes of death among individuals with DS
(n = 761)
Underlying causes of death among individuals with ID (DS excluded)
(n = 3977)
Underlying causes of death among matched samples from the control population
(n = 8364)
Ch. IX – Diseases of the circulatory system
(I00-I99)
n = 122 n = 1368 n = 2959
I50 Heart failure (25.4%) I21 Acute myocardial infarction (23.3%) I21 Acute myocardial infarction (24.1%)
I21 Acute myocardial infarction (14.8%) I25 Chronic ischaemic heart disease (16.6%) I25 Chronic ischaemic heart disease (21.3%)
I25 Chronic ischaemic heart disease (12.3%) I50 Heart failure (11.8%) I50 Heart failure (7.7%)
Ch. X – Diseases of the respiratory system
(J00-J99)
n = 51 n = 468 n = 530
J69 Pneumonitis due to solids and liquids (31.4%) J18 Pneumonia, organism unspecified (50.0%) J44 Other chronic obstructive pulmonary disease (48.9%)
J18 Pneumonia, organism unspecified (19.6%) J44 Other chronic obstructive pulmonary disease (19.9%) J18 Pneumonia, organism unspecified (24.5%)
J45 Asthma (7.8%) J69 Pneumonitis due to solids and liquids (10.0%) J84 Other interstitial pulmonary diseases (8.7%)
J20 Acute bronchitis (7.8%)
J98 Other respiratory disorders (7.8%)
Ch. II – Neoplasms in men
(C00-D48)
n = 9 n = 381 n = 1555
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs (33.3%) C18 Malignant neoplasm of colon (12.9%) C34 Malignant neoplasm of bronchus and lung (18.3%)
C25 Malignant neoplasm of pancreas (11.1%) C61 Malignant neoplasm of prostate (10.5%) C61 Malignant neoplasm of prostate (16.5%)
C67 Malignant neoplasm of bladder (11.1%) C34 Malignant neoplasm of bronchus and lung (7.1%) C25 Malignant neoplasm of pancreas (6.8%)
C16 Malignant neoplasm of stomach (11.1%)
C90 Multiple myeloma and malignant plasma cell neoplasms (11.1%)
C76 Malignant neoplasm of other and ill-defined sites (11.1%)
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx (11.1%)
Ch. II – Neoplasms in women
(C00-D48)
n = 6 n = 313 n = 1194
C67 Malignant neoplasm of bladder (16.7%) C50 Malignant neoplasm of breast (13.4%) C34 Malignant neoplasm of bronchus and lung (19.9%)
C24 Malignant neoplasm of other and unspecified parts of biliary tract (16.7%) C18 Malignant neoplasm of colon (9.3%) C50 Malignant neoplasm of breast (13.0%)
C26 Malignant neoplasm of other and ill-defined digestive organs (16.7%) C34 Malignant neoplasm of bronchus and lung (8.6%) C25 Malignant neoplasm of pancreas (8.0%)
C22 Malignant neoplasm of liver and intrahepatic bile ducts (16.7%)
C57 Malignant neoplasm of other and unspecified female genital organs (16.7%)
C76 Malignant neoplasm of other and ill-defined sites (16.7%)
Ch. VI – Diseases of the nervous system
(G00-G99)
n = 35 n = 218 n = 325
G30 Alzheimer disease (54.3%) G40 Epilepsy (21.6%) G30 Alzheimer disease (44.0%)
G40 Epilepsy (37.1%) G80 Cerebral palsy (19.3%) G20 Parkinson disease (15.7%)
G31 Other degenerative diseases of nervous system, not elsewhere classified (5.7%) G30 Alzheimer disease (10.1%) G12 Spinal muscular atrophy and related syndromes (12.0%)
  1. ICD-10, International Classification of Diseases, Tenth Revision. The proportions presented in this table refer to the number of deaths related to a specific cause (3-digit ICD-10 code) divided by the total number of individuals who died within the disease category group (chapter code) as shown in each cell. In other words, the percentages refer to proportionate mortality within each chapter for each group. When ties of percentages were observed in the three leading causes of death, all causes with tie percentages were presented