Blood pressure at age 60–65 versus age 70–75 and vascular dementia: a population based observational study

Peng, Mingkai; Chen, Guanmin; Tang, Karen L.; Quan, Hude; Smith, Eric E.; Faris, Peter; Hachinski, Vladimir; Campbell, Norm R. C.

doi:10.1186/s12877-017-0649-3

BMC Geriatrics

Table 3 Association between Pulse pressure levels and vascular dementia stratified by blood pressure levels in age 60–65 cohort

From: Blood pressure at age 60–65 versus age 70–75 and vascular dementia: a population based observational study

Pulse pressure (PP) (mmHg)	N	Death, %	VaD, %	Hazard ratio^a (95% CI)	P value	Hazard ratio^b (95% CI)	P value	Hazard ratio^c (95% CI)	P value
Age 60–65 cohort – untreated with antihypertensive drug
Prehypertension
PP ≤ 50	32,434	13.56	0.52	1.00 (reference)		1.00 (reference)		1.00 (reference)
50 < PP ≤ 60	20,007	12.60	0.59	1.01 (0.77, 1.33)	0.95	1.14 (0.88, 1.48)	0.32	0.99 (0.75, 1.30)	0.93
60 < PP ≤ 70	3503	13.79	0.51	0.92 (0.53, 1.60)	0.77	1.07 (0.64, 1.80)	0.79	0.88 (0.51, 1.53)	0.65
PP > 70	217	15.21	0.92	2.15 (0.53, 8.71)	0.28	2.63 (0.64, 1.08)	0.18	2.00 (0.49, 8.15)	0.33
Stage 1 hypertension
PP ≤ 50	8330	16.47	0.79	1.00 (reference)		1.00 (reference)		1.00 (reference)
50 < PP ≤ 60	27,993	15.63	0.68	0.79 (0.58, 1.07)	0.13	1.02 (0.74, 1.40)	0.93	0.78 (0.57, 1.06)	0.11
60 < PP ≤ 70	26,983	15.28	0.65	0.70 (0.51, 0.96)	0.028	0.97 (0.70, 1.34)	0.84	0.68 (0.49, 0.94)	0.018
PP > 70	7885	16.89	0.55	0.59 (0.38, 0.91)	0.016	0.95 (0.62, 1.44)	0.80	0.56 (0.36, 0.87)	0.009
Stage 2 hypertension
PP ≤ 50	1162	19.88	0.86	1.00 (reference)		1.00 (reference)		1.00 (reference)
50 < PP ≤ 60	1393	19.45	0.72	1.10 (0.38, 3.15)	0.86	0.62 (0.23, 1.67)	0.35	1.09 (0.38, 3.14)	0.87
60 < PP ≤ 70	6647	20.19	0.92	1.41 (0.61, 3.28)	0.42	0.85 (0.42, 1.73)	0.65	1.42 (0.61, 3.29)	0.42
PP > 70	19,995	21.24	0.81	1.02 (0.45, 2.31)	0.96	0.80 (0.41, 1.57)	0.52	1.03 (0.46, 2.34)	0.94
Age 60–65 cohort – treated with antihypertensive drug
Prehypertension
PP ≤ 50	9363	20.06	0.68	1.00 (reference)		1.00 (reference)		1.00 (reference)
50 < PP ≤ 60	11,113	17.39	0.62	0.84 (0.57, 1.23)	0.37	0.97 (0.68, 1.39)	0.87	0.83 (0.56, 1.22)	0.33
60 < PP ≤ 70	2131	19.05	0.80	1.19 (0.66, 2.15)	0.57	1.41 (0.81, 2.47)	0.23	1.13 (0.61, 2.10)	0.70
PP > 70	100	17.00	0.00	N/A	N/A	N/A	N/A	N/A	N/A
Stage 1 hypertension
PP ≤ 50	2648	20.70	0.72	1.00 (reference)		1.00 (reference)		1.00 (reference)
50 < PP ≤ 60	14,601	17.81	0.78	1.39 (0.74, 2.62)	0.30	1.11 (0.65, 1.88)	0.71	1.38 (0.73, 2.59)	0.32
60 < PP ≤ 70	21,800	16.64	0.75	1.32 (0.71, 2.47)	0.38	1.08 (0.64, 1.81)	0.78	1.29 (0.69, 2.40)	0.43
PP > 70	8178	18.22	0.69	1.31 (0.67, 2.55)	0.43	1.01 (0.57, 1.79)	0.97	1.24 (0.63, 2.42)	0.53
Stage 2 hypertension
PP ≤ 50	405	26.67	0.49	1.00 (reference)		1.00 (reference)		1.00 (reference)
50 < PP ≤ 60	835	21.92	1.08	1.68 (0.35, 8.14)	0.52	1.78 (0.37, 8.50)	0.47	1.61 (0.33, 7.81)	0.56
60 < PP ≤ 70	4638	21.84	1.01	1.46 (0.35, 6.17)	0.60	1.49 (0.35, 6.26)	0.59	1.41 (0.33, 5.93)	0.64
PP > 70	19,787	22.85	0.83	1.09 (0.26, 4.51)	0.90	1.29 (0.31, 5.33)	0.73	1.02 (0.25, 4.24)	0.98

VaD: Vascular dementia; CI: Confidence interval
^aAdjusted for sex (female = 1) and age
^bAdjusted for sex (female = 1), age, body mass index, smoking status, history of diabetes, stroke, transient ischemic attack, head injury and Parkinson’ disease while excluding any individuals with missing values
^cAdjusted for sex (female = 1), age, body mass index, smoking status, history of diabetes, stroke, transient ischemic attack, head injury and Parkinson’ disease with missing values imputed by multiple imputation method

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ISSN: 1471-2318

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