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Table 1 Association between blood pressure levels and vascular dementia in age 60–65 and 70–75 cohorts

From: Blood pressure at age 60–65 versus age 70–75 and vascular dementia: a population based observational study

Blood pressure levels

N

Death, %

VaD, %

Hazard ratioa (95% CI)

P value

Hazard ratiob (95% CI)

P value

Hazard ratioc (95% CI)

P value

Age 60–65 cohort – untreated with antihypertensive drug

 Normal

10,335

13.49

0.39

1.00 (reference)

   

1.00 (reference)

 

 Prehypertension

56,231

13.24

0.55

1.50 (1.02, 2.20)

0.04

1.25 (0.88, 1.77)

0.21

1.53 (1.04, 2.25)

0.03

 Stage 1 hypertension

71,191

15.73

0.66

1.84 (1.26, 2.68)

0.002

1.46 (1.03, 2.05)

0.032

1.90 (1.30, 2.78)

0.001

 Stage 2 hypertension

29,197

20.86

0.83

2.09 (1.41, 3.10)

<0.001

1.49 (1.04, 2.13)

0.03

2.19 (1.48, 3.26)

< 0.001

Age 60–65 cohort – treated with antihypertensive drug

 Normal

3344

25.60

0.84

1.00 (reference)

 

1.00 (reference)

 

1.00 (reference)

 

 Prehypertension

22,707

18.64

0.66

0.92 (0.56, 1.52)

0.75

0.90 (0.58, 1.40)

0.64

0.91 (0.55, 1.50)

0.71

 Stage 1 hypertension

47,227

17.50

0.75

1.05 (0.65, 1.69)

0.84

0.97 (0.63, 1.48)

0.88

1.04 (0.65, 1.68)

0.86

 Stage 2 hypertension

25,665

22.70

0.86

1.07 (0.65, 1.75)

0.79

0.92 (0.59, 1.42)

0.70

1.08 (0.66, 1.77)

0.76

Age 70–75 cohort – untreated with antihypertensive drug

 Normal

3269

32.82

1.50

1.00 (reference)

 

1.00 (reference)

 

1.00 (reference)

 

 Prehypertension

24,080

30.32

1.65

1.18 (0.82, 1.72)

0.37

1.07 (0.76, 1.52)

0.69

1.19 (0.82, 1.72)

0.37

 Stage 1 hypertension

46,194

31.58

1.72

1.18 (0.82, 1.69)

0.38

1.13 (0.81, 1.59)

0.47

1.18 (0.82, 1.70)

0.37

 Stage 2 hypertension

30,874

36.97

1.72

1.12 (0.77, 1.62)

0.55

1.09 (0.77, 1.53)

0.64

1.14 (0.79, 1.65)

0.49

Age 70–75 cohort – treated with antihypertensive drug

 Normal

2854

46.74

1.51

1.00 (reference)

 

1.00 (reference)

 

1.00 (reference)

 

 Prehypertension

20,032

36.74

1.81

1.49 (0.94, 2.35)

0.09

1.10 (0.78, 1.54)

0.60

1.50 (0.95, 2.37)

0.085

 Stage 1 hypertension

48,593

33.30

1.91

1.76 (1.12, 2.74)

0.013

1.17 (0.84, 1.63)

0.37

1.78 (1.14, 2.79)

0.011

 Stage 2 hypertension

36,220

38.65

1.89

1.56 (1.00, 2.45)

0.052

1.11 (0.79, 1.54)

0.56

1.60 (1.02, 2.51)

0.041

  1. VaD Vascular dementia, CI Confidence interval
  2. aAdjusted for sex (female = 1) and age
  3. bAdjusted for sex (female = 1), age, body mass index, smoking status, history of diabetes, stroke, transient ischemic attack, head injury and Parkinson’ disease while excluding any individuals with missing values
  4. cAdjusted for sex (female = 1), age, body mass index, smoking status, history of diabetes, stroke, transient ischemic attack, head injury and Parkinson’ disease with missing values imputed by multiple imputation method
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BMC Geriatrics

ISSN: 1471-2318

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