Table 5 Characteristics of all ACT participants at last study visit by quartiles of SPPB slope
SPPB >75th percentile slope (slower decline) (N = 872) | SPPB 50th - 75th percentile slope (N = 803) | SPPB 25th - 50th percentile slope (N = 610) | SPPB <25th percentile slope (faster decline) (N = 528) | |
|---|---|---|---|---|
N (%) | N (%) | N (%) | N (%) | |
Cohort | ||||
Original cohort | 574 (65.8) | 463 (57.7) | 415 (68.0) | 415 (78.6) |
Expansion cohort | 202 (23.2) | 156 (19.4) | 123 (20.2) | 88 (16.7) |
Replacement cohort | 96 (11.0) | 184 (22.9) | 72 (11.8) | 25 (4.7) |
Sex | ||||
Male | 410 (47.0) | 371 (46.2) | 229 (37.5) | 164 (31.1) |
Female | 462 (53.0) | 432 (53.8) | 381 (62.5) | 364 (68.9) |
Age at baseline | ||||
< 70 years | 33 (3.8) | 120 (14.9) | 48 (7.9) | 26 (4.9) |
70–74 years | 143 (16.4) | 255 (31.8) | 149 (24.4) | 123 (23.3) |
75–79 years | 241 (27.6) | 189 (23.5) | 149 (24.4) | 172 (32.6) |
80–84 years | 246 (28.2) | 133 (16.6) | 157 (25.7) | 146 (27.7) |
85+ years | 209 (24.0) | 106 (13.2) | 107 (17.5) | 61 (11.6) |
BMI at last ACT study visit | ||||
Underweight (<18.5) | 15 (1.7) | 12 (1.5) | 6 (1.0) | 2 (0.4) |
Normal weight (18.5–24.99) | 354 (41.1) | 283 (35.6) | 182 (30.3) | 142 (27.4) |
Overweight (25–29.99) | 378 (43.9) | 332 (41.8) | 241 (40.1) | 202 (39.0) |
Obese (30+) | 114 (13.2) | 168 (21.1) | 172 (28.6) | 172 (33.2) |
Dementia | ||||
No dementia | 698 (80.0) | 638 (79.5) | 423 (69.3) | 361 (68.4) |
Dementia | 174 (20.0) | 165 (20.5) | 187 (30.7) | 167 (31.6) |
Possible or probable AD | ||||
No AD | 720 (82.6) | 672 (83.7) | 461 (75.6) | 398 (75.4) |
AD | 152 (17.4) | 131 (16.3) | 149 (24.4) | 130 (24.6) |
Education | ||||
< 12 years | 89 (10.2) | 71 (8.8) | 69 (11.3) | 67 (12.7) |
12–15 years | 395 (45.3) | 366 (45.6) | 316 (51.8) | 315 (59.7) |
16+ years | 388 (44.5) | 366 (45.6) | 225 (36.9) | 146 (27.7) |
Smoking at last visit | ||||
Never | 427 (49.5) | 378 (47.3) | 300 (49.5) | 241 (45.9) |
Former | 419 (48.6) | 390 (48.8) | 270 (44.6) | 260 (49.5) |
Current | 17 (2.0) | 31 (3.9) | 36 (5.9) | 24 (4.6) |
Regular exercise at last visit | ||||
No | 222 (25.7) | 262 (32.8) | 234 (38.5) | 258 (49.2) |
Yes | 643 (74.3) | 537 (67.2) | 374 (61.5) | 266 (50.8) |
SPPB: gait speeda component (0–4) at baseline | ||||
1 | 14 (1.6) | 35 (4.4) | 42 (6.9) | 102 (19.3) |
2 | 31 (3.6) | 60 (7.5) | 59 (9.7) | 91 (17.2) |
3 | 260 (29.8) | 267 (33.3) | 251 (41.1) | 194 (36.7) |
4 | 567 (65.0) | 441 (54.9) | 258 (42.3) | 141 (26.7) |
Grip strengtha at baseline | ||||
0 | 9 (1.0) | 8 (1.0) | 6 (1.0) | 3 (0.6) |
1 | 40 (4.6) | 59 (7.3) | 66 (10.8) | 67 (12.7) |
2 | 145 (16.6) | 152 (18.9) | 137 (22.5) | 145 (27.6) |
3 | 382 (43.8) | 331 (41.2) | 249 (40.8) | 209 (39.7) |
4 | 296 (33.9) | 253 (31.5) | 152 (24.9) | 102 (19.4) |