Table 2 Unadjusted proportions for binary neuropathology outcomes according to quartilesa of SPPB slope
SPPB >75th percentile slope (slower decline) (N = 76) | SPPB 50th - 75th percentile slope (N = 76) | SPPB 25th - 50th percentile slope (N = 76) | SPPB <25th percentile slope (faster decline) (N = 77) | |
|---|---|---|---|---|
N (%) | N (%) | N (%) | N (%) | |
CERAD (plaques) | ||||
Intermediate/frequent | 40 (52.6) | 31 (40.8) | 35 (46.1) | 41 (53.2) |
None/sparse | 36 (47.4) | 45 (59.2) | 41 (53.9) | 36 (46.8) |
Braak (tangles) | ||||
V-VI | 29 (38.2) | 17 (22.4) | 25 (32.9) | 25 (32.5) |
0-IV | 47 (61.8) | 59 (77.6) | 51 (67.1) | 52 (67.5) |
Amyloid angiopathy | ||||
Mild, moderate, or severe | 25 (32.9) | 23 (30.7) | 18 (24.0) | 22 (28.6) |
None | 51 (67.1) | 52 (69.3) | 57 (76.0) | 55 (71.4) |
Microinfarcts | ||||
> 2 cerebral or deep | 8 (10.5) | 5 (6.6) | 9 (11.8) | 21 (27.3) |
< = 2 cerebral or deep | 68 (89.5) | 71 (93.4) | 67 (88.2) | 56 (72.7) |
Cystic infarcts | ||||
1 or more | 14 (18.9) | 22 (30.1) | 25 (34.2) | 24 (31.2) |
None | 60 (81.1) | 51 (69.9) | 48 (65.8) | 53 (68.8) |
Atherosclerosis | ||||
2–3 | 45 (62.5) | 44 (58.7) | 35 (50.0) | 48 (63.2) |
0–1 | 27 (37.5) | 31 (41.3) | 35 (50.0) | 28 (36.8) |
Cortical Lewy bodies | ||||
1 | 3 (3.9) | 6 (8.0) | 5 (6.6) | 3 (3.9) |
0 | 73 (96.1) | 69 (92.0) | 71 (93.4) | 74 (96.1) |