SPPB >75th percentile slope (slower decline) (N = 76) | SPPB 50th - 75th percentile slope (N = 76) | SPPB 25th - 50th percentile slope (N = 76) | SPPB <25th percentile slope (faster decline) (N = 77) | |
---|---|---|---|---|
N (%) | N (%) | N (%) | N (%) | |
Cohort | ||||
Original cohort | 62 (81.6) | 66 (86.8) | 64 (84.2) | 70 (90.9) |
Expansion cohort | 14 (18.4) | 9 (11.8) | 12 (15.8) | 6 (7.8) |
Replacement cohort | 0 (0.0) | 1 (1.3) | 0 (0.0) | 1 (1.3) |
Sex | ||||
Male | 44 (57.9) | 38 (50.0) | 33 (43.4) | 25 (32.5) |
Female | 32 (42.1) | 38 (50.0) | 43 (56.6) | 52 (67.5) |
Age at baseline | ||||
< 70 years | 0 (0.0) | 4 (5.3) | 4 (5.3) | 3 (3.9) |
70–74 years | 5 (6.6) | 18 (23.7) | 12 (15.8) | 12 (15.6) |
75–79 years | 21 (27.6) | 10 (13.2) | 16 (21.1) | 28 (36.4) |
80–84 years | 27 (35.5) | 21 (27.6) | 22 (28.9) | 23 (29.9) |
85+ years | 23 (30.3) | 23 (30.3) | 22 (28.9) | 11 (14.3) |
BMI at last ACT study visit | ||||
Underweight (<18.5) | 3 (4.0) | 0 (0.0) | 1 (1.4) | 1 (1.3) |
Normal weight (18.5–24.99) | 34 (45.3) | 39 (54.2) | 31 (42.5) | 23 (30.7) |
Overweight (25–29.99) | 33 (44.0) | 25 (34.7) | 25 (34.2) | 34 (45.3) |
Obese (30+) | 5 (6.7) | 8 (11.1) | 16 (21.9) | 17 (22.7) |
Dementia | ||||
No dementia | 44 (57.9) | 39 (51.3) | 43 (56.6) | 37 (48.1) |
Dementia | 32 (42.1) | 37 (48.7) | 33 (43.4) | 40 (51.9) |
Possible or probable AD | ||||
No AD | 47 (61.8) | 51 (67.1) | 51 (67.1) | 46 (59.7) |
AD | 29 (38.2) | 25 (32.9) | 25 (32.9) | 31 (40.3) |
Education | ||||
< 12 years | 3 (3.9) | 15 (19.7) | 8 (10.5) | 7 (9.1) |
12–15 years | 37 (48.7) | 33 (43.4) | 40 (52.6) | 47 (61.0) |
16+ years | 36 (47.4) | 28 (36.8) | 28 (36.8) | 23 (29.9) |
Smoking at last visit | ||||
Never | 30 (39.5) | 32 (42.1) | 31 (40.8) | 27 (35.1) |
Former | 42 (55.3) | 40 (52.6) | 40 (52.6) | 44 (57.1) |
Current | 4 (5.3) | 4 (5.3) | 5 (6.6) | 6 (7.8) |
Regular exercise at last visit | ||||
No | 21 (28.0) | 21 (27.6) | 36 (48.0) | 36 (47.4) |
Yes | 54 (72.0) | 55 (72.4) | 39 (52.0) | 40 (52.6) |
SPPB: gait speeda component (0–4) at baseline | ||||
1 | 1 (1.3) | 4 (5.3) | 9 (11.8) | 15 (19.5) |
2 | 1 (1.3) | 10 (13.2) | 8 (10.5) | 14 (18.2) |
3 | 28 (36.8) | 32 (42.1) | 34 (44.7) | 34 (44.2) |
4 | 46 (60.5) | 30 (39.5) | 25 (32.9) | 14 (18.2) |
Grip strengthb at baseline | ||||
0 | 2 (2.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
1 | 5 (6.6) | 10 (13.2) | 14 (18.4) | 6 (7.8) |
2 | 15 (19.7) | 17 (22.4) | 14 (18.4) | 28 (36.4) |
3 | 39 (51.3) | 31 (40.8) | 30 (39.5) | 33 (42.9) |
4 | 15 (19.7) | 18 (23.7) | 18 (23.7) | 10 (13.0) |