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Table 3 Quality appraisal for intervention studies

From: Efficacy and safety of metformin in the management of type 2 diabetes mellitus in older adults: a systematic review for the development of recommendations to reduce potentially inappropriate prescribing

Source

Type of study

Selection bias

Performance bias

Detection bias

Attrition bias

Reporting bias

 

1. Random sequence generation

2. Allocation concealment

3. Blinding of participants and personnel

4. Blinding of outcome assessment

5. Incomplete outcome data

6. Selective reporting

7. Other bias

Cryer 2005 [31]

Randomised, open label, parallel-group, multicentre, clinical trial

UR

HR

HR

UR

LR

UR

HR

Janka 2007 [35]

Parallel-group, open-label, randomized, multinational clinical trial

LR

LR

HR

HR

LR

LR

LR

Josephkutty 1990 [36]

Randomized double-blind cross-over study

UR

UR

UR

UR

UR

UR

UR

Schweizer 2009 [43]

Randomized, active-controlled, parallel-group study

UR

UR

UR

UR

LR

UR

HR

  1. LR low risk of bias; HR high risk of bias; UR unclear risk of bias