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Table 4 Quality appraisal for intervention studies

From: Effectiveness and safety of dipeptidyl peptidase 4 inhibitors in the management of type 2 diabetes in older adults: a systematic review and development of recommendations to reduce inappropriate prescribing

Source

Type of study

Selection bias

Performance bias

Detection bias

Attrition bias

Reporting bias

 

1. Random sequence generation

2. Allocation concealment

3. Blinding of participants and personnel

4. Blinding of outcome assessment

5. Incomplete outcome data

6. Selective reporting

7. Other bias

Banerji et al. 2010 [29]

Retrospective analysis of the GALIANT study which is a multicenter, randomised, open-label study

LR

HR

HR

HR

LR

UR

HR

Barnett et al. 2013 [31]

Randomised, double-blind, placebo-controlled trial

LR

LR

LR

UR

LR

LR

UR

Barzilai et al. 2011 [30]

Randomised, double-blind, placebo-controlled trial

LR

LR

LR

UR

LR

UR

UR

Chien et al. 2011 [32]

Randomised, open-labelled, parallel-group study

UR

UR

UR

HR

UR

UR

HR

Ferrannini et al. 2009 [54]

Multicentre, randomised, double-blind, active-controlled study

UR

UR

UR

UR

LR

UR

HR

Fonseca et al. 2008 [56]

Multicentre, double-blind, parallel-group, randomised study

UR

UR

UR

UR

LR

UR

HR

Green et al. 2015 [13]

Randomised, double-blind, placebo-controlled study

LR

LR

LR

LR

LR

LR

HR

Hartley et al. 2015 [37]

Randomised, parallel-group, multinational, non-inferiority clinical trial with an active controlled, double-blind treatment period

LR

LR

LR

UR

LR

LR

HR

Kadowaki et al. 2014 [38]

Randomised, double-blind, placebo-controlled study

UR

UR

LR

UR

LR

UR

HR

Matthews et al. 2010 [55]

Multicentre, randomised, double-blind, double-dummy, active-controlled study

UR

UR

LR

UR

LR

UR

HR

Rosenstock et al. 2013 [59]

Multicentre, randomised, double-blind, active controlled study

UR

UR

LR

UR

LR

UR

HR

Schernthaner et al. 2015 [39]

Multinational, randomised, double-blind, phase IIIb/IV study

LR

UR

UR

UR

HR

UR

HR

Schweizer et al. 2009 [40]

Double-blind, randomised, multicentre, active-controlled, parallel-group study

UR

UR

UR

UR

LR

UR

HR

Schweizer et al. 2013 [53]

Post-hoc sub-analysis of a multi-centre, randomised, double-blind, parallel-group

UR

UR

UR

UR

UR

UR

UR

Scirica et al. 2013 [12]

Scirica et al. 2014 [41]

Leiter et al. 2015 [42]

Mosenzon et al. 2015 [43]

Multicentre, randomised, double-blind, placebo-controlled trial

LR

LR

LR

LR

LR

LR

LR

Strain et al. 2013 [52]

Multinational, double-blind, randomised, placebo-controlled

LR

LR

LR

LR

LR

LR

LR

White et al. 2013 [44]

Multicentre, randomised, double-blind placebo-controlled trial

LR

UR

LR

UR

LR

LR

HR

  1. LR Low risk of bias, HR High risk of bias, UR Unclear risk of bias