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Table 1 List of drugs and drug classes covered, corresponding indications and SRs performed

From: A set of systematic reviews to help reduce inappropriate prescribing to older people: study protocol

Drug or drug class Indication
Proton pump inhibitors GERD/GORD (SR-1)
Gastrointestinal ulcer (gastric, duodenal) (SR-1)
Dyspepsia (SR-1)
Anti- inflammatory and anti- rheumatic products, non-steroids (NSAIDs) Musculoskeletal disorders (SR-2)
Opioids Pain (SR-3)
HMG CoA reductase inhibitors (Statins) Prevention of cardiovascular disease (SR-4)
Beta blocking agents Hypertension (SR-5)
Heart failure (SR-6)
Angiotensin Converting Enzyme inhibitors (ACE-I) Hypertension (SR-7)
Low-ceiling diuretics, Thiazides and Sulfonamides Heart failure (SR-8)
Oedema (SR-8)
Hypertension (SR-9)
Calcium Channel Blockers (CCBs) Angina (SR-10)
Hypertension (SR-11)
Nitrates Angina (SR-12)
High ceiling diuretics Heart failure (SR-13)
Oedema (SR-13)
Hypertension (SR-13)
Liver failure (SR-13)
Renal failure (SR-13)
Platelet aggregation inhibitors Prevention and treatment of cardiovascular disease including cerebral infarction and transient ischaemic attack, coronary disease and peripheral artery occlusive disease (SR-14)
Vitamin K antagonists (VKA) Direct thrombin inhibitors and Direct factor Xa inhibitors (New Oral Anticoagulants (NOACs)) Deep vein thrombosis/lung embolism (SR-15)
Thromboembolism in atrial fibrillation (SR-16)
Digitalis glycosides Heart failure (SR-17)
Atrial fibrillation (SR-17)
Metformin Type 2 diabetes (SR-18)
Dipeptidyl peptidase 4 (DPP-4) inhibitors (Gliptins) Type 2 diabetes (SR-19)
Pioglitazone Type 2 diabetes (SR-20)
Sulfonylureas Type 2 diabetes (SR-21)
Glinides Type 2 diabetes (SR-21)
Insulin and analogues Type 2 diabetes (SR-22)
  1. GERD gastroesophageal reflux disease, GORD gastro-oesophageal reflux disease, HMG CoA 3-hydroxy-3-methylglutaryl-coenzyme A, Direct factor Xa inhibitors xabans