Case | Controls | Unadjusted ORa | 95% CI | |||
---|---|---|---|---|---|---|
n = 2238 | % | n = 8645 | % | |||
Sex | NA | |||||
Female | 1359 | 60.7 | 5222 | 60.4 | ||
Male | 879 | 39.3 | 3423 | 39.6 | ||
Age, years | NA | |||||
65–74 | 765 | 34.2 | 3046 | 35.2 | ||
75–84 | 958 | 42.8 | 3800 | 44.0 | ||
≥ 85 | 515 | 23.0 | 1799 | 20.8 | ||
Index year | NA | |||||
2003 | 175 | 7.8 | 682 | 7.9 | ||
2004 | 214 | 9.6 | 836 | 9.7 | ||
2005 | 211 | 9.4 | 817 | 9.5 | ||
2006 | 218 | 9.7 | 855 | 9.9 | ||
2007 | 257 | 11.5 | 1005 | 11.6 | ||
2008 | 255 | 11.4 | 979 | 11.3 | ||
2009 | 248 | 11.1 | 959 | 11.1 | ||
2010 | 217 | 9.7 | 835 | 9.7 | ||
2011 | 226 | 10.1 | 848 | 9.8 | ||
2012 | 217 | 9.7 | 829 | 9.6 | ||
Comorbidities within 365 days before index date | ||||||
Dementia | 197 | 8.8 | 550 | 6.4 | 1.40 | 1.18–1.67 |
Epilepsy | 25 | 1.1 | 94 | 1.1 | 1.03 | 0.66–1.61 |
Parkinson’s disease | 165 | 7.4 | 333 | 3.9 | 1.98 | 1.64–2.40 |
Cerebrovascular disease | 547 | 24.4 | 1758 | 20.3 | 1.27 | 1.13–1.42 |
Diabetes | 629 | 28.1 | 2315 | 26.8 | 1.09 | 0.98–1.21 |
Hypertension | 1296 | 57.9 | 5661 | 65.5 | 0.73 | 0.66–0.80 |
Ischemia Heart Disease | 491 | 21.9 | 2341 | 27.1 | 0.76 | 0.68–0.85 |
Medication exposure within 365 days before index date | ||||||
Antipsychotics | 328 | 14.7 | 1011 | 11.7 | 1.31 | 1.14–1.50 |
Antidepressants | 386 | 17.3 | 1089 | 12.6 | 1.45 | 1.28–1.65 |
Anticonvulsants | 129 | 5.8 | 458 | 5.3 | 1.11 | 0.91–1.36 |
Thiazide Diuretics | 235 | 10.5 | 1140 | 13.2 | 0.78 | 0.67–0.90 |
Opioids | 378 | 16.9 | 687 | 8.0 | 2.38 | 2.07–2.73 |
Mean | SD | Mean | SD | |||
Age (years) | 77.7 | 7.2 | 77.3 | 7.0 | NA | |
Charlson Comorbidity Index score | 1.4 | 1.5 | 1.5 | 1.5 | 0.98 | 0.95–1.01 |
Numbers of outpatient services in the 180 days before index date | 16.5 | 13.9 | 19.6 | 13.1 | 0.98 | 0.98–0.99 |