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Table 5 Prediction of the diagnosis of Alzheimer’s disease in an out-patient population referred for evaluation of dementia (blinded study)

From: Olfactory testing in consecutive patients referred with suspected dementia

 

Alzheimers disease

P a

ORb

95-CI

P c

ORc

95-CI

PPV (%)f

NPV (%)g

Number of smell errors

1+ (0 reference)

0.045

nad

  

nad

 

52

100

2+ (0–1 reference)

0.011

12.2

1.4–105

0.026

11.6

1.3–101

58

90

3+ (0–2 reference)

0.059

3.3

0.9–11.4

0.078

3.3

0.9–12.1

58

71

4+ (0–3 reference)

0.093

2.7

0.8–8.8

0.055

3.5

1.0–12.6

63

61

5+ (0–4 reference)

0.62

1.4

0.3–6.2

0.73

1.3

0.3–6.6

56

54

6 (0–5 reference)

0.10

nae

  

nae

 

100

55

  1. aChi squared test, Fisher’s exact test if n < 5
  2. bUnivariate logistic regression
  3. cMultivariate model adjusted for age (<80y) and MMSE (<20)
  4. dNot applicable: 4, all non-AD
  5. eNot applicable: 3 reference, all AD
  6. fPositive predictive value, %
  7. gNegative predictive value, %