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Table 2 Hazard ratios for time to death post-discharge by quartiles of markers in patients without cancer diagnoses

From: Association between routine laboratory tests and long-term mortality among acutely admitted older medical patients: a cohort study

 

Unadjusted)

Adjusted

Fully adjusted model

FI-OutRef1

Age

No. of chronic diagnoses

New chronic diagnoses

New acute admissions

FI-OutRef1)

P < .0001

 

P < .0001

P < .0001

P < .0001

P < .0001

P < .0001

 Quartile 2

2.09

(1.69–2.58)

  

1.94

(1.57–2.40)

2.01

(1.62–2.48)

2.05

(1.66–2.54)

2.05

(1.66–2.53)

1.92

(1.55–2.37)

 Quartile 3

3.25

(2.65–3.99)

  

2.84

(2.31–3.49)

3.12

(2.54–3.84)

3.18

(2.60–3.91)

3.18

(2.59–3.90)

2.73

(2.22–3.36)

 Quartile 4

4.07

(3.33–4.97)

  

3.66

(3.00–4.48)

3.85

(3.15–4.71)

4.01

(3.28–4.90)

3.89

(3.18–4.76)

3.48

(2.84–4.26)

Age

P < .0001

P < .0001

 

<.0001

P < .0001

P < .0001

P < .0001

 Quartile 2

1.52

(1.26–1.83)

1.41

(1.15–1.74)

  

1.48

(1.22–1.78)

1.51

(1.25–1.82)

1.51

(1.26–1.82)

1.42

(1.15–1.75)

 Quartile 3

2.25

(1.88–2.68)

2.05

(1.69–2.50)

  

2.13

(1.77–2.53)

2.25

(1.88–2.68)

2.17

(1.82–2.60)

1.99

(1.63–2.42)

 Quartile 4

3.60

(3.04–4.27)

3.14

(2.60–3.80)

  

3.50

(2.95–4.16)

3.69

(3.11–4.38)

3.55

(3.00–4.21)

3.15

(2.60–3.81)

No. of chronic diagnoses

P < .0001

P < .0001

P < .0001

 

P < .0001

P < .0001

P 0.07

 Quartile 2

1.42

(1.21–1.68)

1.41

(1.18–1.68)

1.31

(1.11–1.54)

  

1.45

(1.22–1.72)

1.32

(1.12–1.56)

1.28

(1.06–1.54)

 Quartile 3

1.66

(1. 40–1.98)

1.56

(1.28–1.88)

1.50

(1.26–1.79)

  

1.68

(1.39–2.03)

1.42

(1.18–1.71)

1.32

(1.07–1.63)

 Quartile 4

1.93

(1.63–2.27)

1.73

(1.43–2.05)

1.82

(1.54–2.14)

  

1.87

(1.55–2.26)

1.57

(1.31–1.88)

1.44

(1.17–1.78)

New chronic diagnoses

P < .0001

P < .0001

P < .0001

P 0.060

 

P < .0001

P 0.029

 Quartile 2

0.98

(0.83–1.15)

0.95

(0.79–1.13)

0.98

(0.83–1.16)

0.87

(0.74–1.04)

  

0.84

(0.71–1.00)

0.84

(0.69–1.02)

 Quartile 3

1.09

(0.93–1.27)

1.01

(0.85–1.20)

1.07

(0.92–1.25)

0.88

(0.75–1.05)

  

0.86

(0.72–1.02)

0.81

(0.66–0.98)

 Quartile 4

1.48

(1.27–1.71)

1.33

(1.13–1.57)

1.56

(1.35–1.81)

1.07

(0.90–1.27)

  

1.03

(0.86–1.23)

1.01

(0.82–1.24)

New acute admissions

P < .0001

P < .0001

P < .0001

P < .0001

P < .0001

 

P <0.001

 Quartile 2

1.23

(1.06–1.43)

1.15

(0.97–1.35)

1.15

(0.99–1.34)

1.12

(0.96–1.31)

1.27

(1.08–1.49)

  

1.12

(0.94–1.32)

 Quartile 3

1.65

(1.39–1.97)

1.35

(1.11–1.64)

1.53

(1.28–1.82)

1.43

(1.19–1.72)

1.69

(1.39–2.04)

  

1.23

(0.99–1.53)

 Quartile 4

1.87

(1.61–2.17)

1.65

(1.40–1.94)

1.82

(1.57–2.11)

1.57

(1.33–1.85)

1.88

(1.58–2.25)

  

1.49

(1.22–1.81)

  1. Univariate- and multivariate survival analyses regarding mortality within 3 years from discharge in acutely admitted older medical patients by nearest possible quartiles of addressed variables. Columns indicate adjusting covariates in the multivariate survival analysis. Fully adjusted model: adjusted for all of the other addressed covariates and sex. FI-OutRef frailty index by the number of laboratory test results outside the reference interval in the standard panel of laboratory tests at admission, No. of chronic diagnoses total number of unique chronic diagnoses within the 10-year period prior to the index admission, New chronic diagnoses, the number of chronic diagnoses given in the 2-year period up to the index admission, New acute admissions number of new acute admissions within the 2-year period up to the index admission 1) Analyses for FI-OutRef includes 2,442 of the total 2,965 discharged patients who had 10 or more standard laboratory tests at admission
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BMC Geriatrics

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