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Table 5 Predictors of mortality (medications) after hip fracture in AD and non-AD cohorts (persons with previous fractures excluded)

From: Comparison of predictors of hip fracture and mortality after hip fracture in community-dwellers with and without Alzheimer’s disease – exposure-matched cohort study

Risk factor Category AD cohort Non-AD cohort
Mortality/ 100 PY Unadjusted HR
(95% CI)
Adjusted HRa
(95% CI)
Mortality/ 100 PY Unadjusted HR
(95% CI)
Adjusted HRa
(95% CI)
Any CVD medication Yes 31.6 1.12 (1.03–1.22) 1.18 (1.08–1.29) 28.1 1.25 (1.02–1.54) 1.28 (1.04–1.58)
No 24.7 1.00 (reference) 1.00 (reference) 17.4 1.00 (reference) 1.00 (reference)
Yes 30.0 1.17 (1.05–1.31) 1.17 (1.04–1.31) 24.0 1.36 (1.06–1.74) 1.37 (1.07–1.76)
Drugs for obstructive airway diseases No 28.3 1.00 (reference) 1.00 (reference) 23.1 1.00 (reference) 1.00 (reference)
Yes 35.3 1.25 (1.12–1.39) 1.17 (1.05–1.30) 24.3 1.04 (0.88–1.23) 1.11 (0.94–1.32)
Hormone therapy No 29.8 1.00 (reference) 1.00 (reference) 23.7 1.00 (reference) 1.00 (reference)
  Yes 18.6 0.63 (0.49–0.80) 0.81 (0.64–1.04) 11.7 0.50 (0.29–0.85) 0.78 (0.46–1.32)
Bisphosphonates No 29.5 1.00 (reference) 1.00 (reference) 23.7 1.00 (reference) 1.00 (reference)
  Yes 28.1 0.95 (0.85–1.07) 1.07 (0.95–1.20) 21.0 0.88 (0.72–1.06) 1.06 (0.87–1.29)
Proton pump inhibitors No 26.8 1.00 (reference) 1.00 (reference) 21.0 1.00 (reference) 1.00 (reference)
Yes 33.4 1.24 (1.15–1.35) 1.25 (1.15–1.36) 26.8 1.27 (1.12–1.45) 1.31 (1.15–1.49)
Anti–Parkinson drugs No 29.28 1.00 (reference) 1.00 (reference) 23.12 1.00 (reference) 1.00 (reference)
Yes 29.10 0.99 (0.84–1.18) 1.02 (0.86–1.21) 27.15 1.18 (0.91–1.54) 1.20 (0.92–1.56)
Antiepileptics drugs No 29.0 1.00 (reference) 1.00 (reference) 23.6 1.00 (reference) 1.00 (reference)
  Yes 31.9 1.10 (0.96–1.25) 1.12 (0.99–1.28) 21.2 0.90 (0.72–1.11) 0.98 (0.79–1.21)
Antipsychotics No 28.2 1.00 (reference) 1.00 (reference) 22.3 1.00 (reference) 1.00 (reference)
  Yes 31.1 1.10 (1.01–1.20) 1.16 (1.06–1.26) 30.9 1.41 (1.18–1.68) 1.41 (1.18–1.68)
Antidepressants No 30.7 1.00 (reference) 1.00 (reference) 22.1 1.00 (reference) 1.00 (reference)
  Yes 27.5 0.89 (0.82–0.97) 0.97 (0.89–1.05) 26.9 1.22 (1.05–1.40) 1.29 (1.11–1.48)
BZDRS No 28.4 1.00 (reference) 1.00 (reference) 21.3 1.00 (reference) 1.00 (reference)
  Yes 30.2 1.06 (0.98–1.15) 1.06 (0.98–1.15) 25.7 1.21 (1.06–1.38) 1.18 (1.04–1.35)
Opioids No 25.5 1.00 (reference) 1.00 (reference) 18.7 1.00 (reference) 1.00 (reference)
  Yes 32.9 1.30 (1.20–1.41) 1.29 (1.19–1.40) 28.5 1.50 (1.31–1.72) 1.56 (1.36–1.79)
  1. aAdjusted for occupational social class
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