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Table 3 Hip fracture risk factors (medications) in AD and non-AD cohorts (persons with previous fractures excluded)

From: Comparison of predictors of hip fracture and mortality after hip fracture in community-dwellers with and without Alzheimer’s disease – exposure-matched cohort study

Risk factor Category AD cohort Non-AD cohort
IR/ 100 PY Unadjusted
HR (95% CI)
Adjusted HRa
(95% CI)
IR/ 100 PY Unadjusted HR
HR (95% CI)
Adjusted HRa
HR (95% CI)
Any CVD medication No 2.21 1.00 (reference) 1.00 (reference) 0.63 1.00 (reference) 1.00 (reference)
Yes 2.18 0.99 (0.91–1.06) 0.84 (0.78–0.91) 0.98 1.54 (1.37–1.73) 1.02 (0.91–1.15)
Drugs for obstructive airway diseases No 2.21 1.00 (reference) 1.00 (reference) 0.90 1.00 (reference) 1.00 (reference)
Yes 2.11 0.96 (0.89–1.02) 0.97 (0.90–1.03) 0.92 1.01 (0.92–1.11) 1.00 (0.91–1.11)
Hormone therapy No 2.23 1.00 (reference) 1.00 (reference) 0.93 1.00 (reference) 1.00 (reference)
  Yes 1.66 0.74 (0.66–0.84) 0.87 (0.77–0.98) 0.51 0.54 (0.44–0.67) 0.79 (0.64–0.98)
Bisphosphonates No 2.13 1.00 (reference) 1.00 (reference) 0.88 1.00 (reference) 1.00 (reference)
  Yes 2.58 1.21 (1.12–1.31) 0.97 (0.90–1.05) 1.14 1.29 (1.14–1.46) 0.96 (0.85–1.08)
Proton pump inhibitors No 2.18 1.00 (reference) 1.00 (reference) 0.83 1.00 (reference) 1.00 (reference)
  Yes 2.19 1.00 (0.94–1.07) 0.96 (0.90–1.02) 1.07 1.27 (1.17–1.39) 1.14 (1.05–1.25)
Anti-Parkinson drugs No 2.16 1.00 (reference) 1.00 (reference) 0.88 1.00 (reference) 1.00 (reference)
Yes 2.95 1.36 (1.19–1.57) 1.46 (1.27–1.68) 1.66 1.86 (1.53–2.26) 1.67 (1.38–2.03)
Antiepileptics drugs No 2.20 1.00 (reference) 1.00 (reference) 0.88 1.00 (reference) 1.00 (reference)
Yes 2.09 0.95 (0.86–1.05) 0.99 (0.90–1.09) 1.23 1.37 (1.19–1.57) 1.27 (1.11–1.46)
Antipsychotics No 2.12 1.00 (reference) 1.00 (reference) 0.85 1.00 (reference) 1.00 (reference)
  Yes 2.53 1.20 (1.11–1.29) 1.12 (1.04–1.20) 1.64 1.95 (1.73–2.20) 1.56 (1.38–1.76)
Antidepressants No 2.14 1.00 (reference) 1.00 (reference) 0.83 1.00 (reference) 1.00 (reference)
  Yes 2.28 1.07 (1.00–1.13) 1.06 (1.00–1.12) 1.24 1.49 (1.36–1.64) 1.34 (1.22–1.47)
BZDRS No 2.04 1.00 (reference) 1.00 (reference) 0.74 1.00 (reference) 1.00 (reference)
  Yes 2.39 1.17 (1.11–1.24) 1.03 (0.97–1.09) 1.18 1.58 (1.45–1.71) 1.22 (1.12–1.32)
Opioids No 2.09 1.00 (reference) 1.00 (reference) 0.80 1.00 (reference) 1.00 (reference)
  Yes 2.34 1.12 (1.05–1.18) 1.00 (0.94–1.06) 1.12 1.36 (1.25–1.48) 1.10 (1.01–1.19)
  1. aAdjusted for occupational social class
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