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Table 2 Hip fracture risk factors (demographic and comorbidities) in AD and non-AD cohorts (persons with previous fractures excluded)

From: Comparison of predictors of hip fracture and mortality after hip fracture in community-dwellers with and without Alzheimer’s disease – exposure-matched cohort study

Risk factor Category AD cohort Non-AD cohort
IR/ 100 PY Unadjusted
HR (95% CI)
Adjusted
HRa (95% CI)
IR/ 100 PY Unadjusted HR
HR (95% CI)
Adjusted HRa
HR (95% CI)
Age at baseline, increase per year 1.07 (1.06–1.07) 1.06 (1.06–1.07) N.A 1.12 (1.11–1.12) 1.12 (1.11–1.13)
Sex Men 2.50 1.00 (reference) 1.00 (reference) 1.05 1.00 (reference) 1.00 (reference)
  Women 1.58 0.63 (0.59–0.68) 0.73 (0.68–0.78) 0.64 0.61 (0.56–0.67) 0.76 (0.69–0.84)
Highest occupational social class before follow-up Managerial/professional 1.83 1.00 (reference) 1.00 (reference) 0.66 1.00 (reference) N.A
Office worker 2.52 1.38 (1.23–1.54) 1.17 (1.04–1.31) 0.95 1.45 (1.23–1.72)  
Farming/forestry 2.05 1.12 (1.02–1.24) 0.95 (0.86–1.04) 0.94 1.45 (1.26–1.66)  
Sales/industry/cleaning 2.15 1.18 (1.08–1.27) 1.04 (0.96–1.13) 0.96 1.47 (1.31–1.66)  
  Unknown 3.27 1.79 (1.62–1.99) 1.19 (1.06–1.32) 1.48 2.30 (1.97–2.68)  
  Did not respond 2.50 1.36 (1.00–1.87) 1.16 (0.85–1.58) 0.25 0.38 (0.25–0.56)  
Hip replacement No 1.22 1.00 (reference) 1.00 (reference) 0.52 1.00 (reference) 1.00 (reference)
  Yes 41.83 42.0 (39.5–44.6) 38.8 (36.5–41.2) 36.47 94.3 (86.4–103.0) 71.2 (65.1–77.9)
Knee replacement No 2.14 1.00 (reference) 1.00 (reference) 0.88 1.00 (reference) 1.00 (reference)
Yes 59.15 28.4 (23.4–34.4) 25.3 (20.8–30.7) 36.84 45.9 (35.9–58.6) 40.3 (31.5–51.5)
Cardiovascular disease No 2.18 1.00 (reference) 1.00 (reference) 0.83 1.00 (reference) 1.00 (reference)
Yes 2.19 1.01 (0.95–1.06) 0.94 (0.89–1.00) 0.98 1.20 (1.11–1.30) 0.99 (0.91–1.07)
Stroke No 2.18 1.00 (reference) 1.00 (reference) 0.86 1.00 (reference) 1.00 (reference)
  Yes 2.30 1.06 (0.96–1.17) 1.05 (0.95–1.16) 1.42 1.67 (1.47–1.89) 1.42 (1.26–1.62)
Diabetes No 2.19 1.00 (reference) 1.00 (reference) 0.89 1.00 (reference) 1.00 (reference)
  Yes 2.14 0.98 (0.90–1.06) 1.03 (0.95–1.13) 0.99 1.11 (0.98–1.26) 1.13 (0.99–1.28)
Cancer treatment No 2.19 1.00 (reference) 1.00 (reference) 0.90 1.00 (reference) 1.00 (reference)
Yes 2.06 0.94 (0.71–1.24) 1.01 (0.76–1.34) 1.31 1.44 (1.05–1.98) 1.67 (1.22–2.30)
Asthma/COPD No 2.18 1.00 (reference) 1.00 (reference) 0.90 1.00 (reference) 1.00 (reference)
  Yes 2.24 1.02 (0.93–1.13) 1.03 (0.94–1.14) 0.95 1.05 (0.91–1.21) 1.07 (0.93–1.23)
Any mental or behavioural disorder No 2.09 1.00 (reference) 1.00 (reference) 0.85 1.00 (reference) 1.00 (reference)
Yes 2.53 1.21 (1.14–1.29) 1.16 (1.09–1.24) 1.53 1.83 (1.63–2.05) 1.71 (1.52–1.92)
  1. aAdjusted for occupational social class
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