Table 1 Patient demographics at baseline for the overall population stratified according to baseline AD dementia severity
Characteristic | Mild AD dementia(N = 200) | Moderate AD dementia (N = 180) | MS/S AD dementia (N = 146) | Overall (N = 526) | P-valuea |
|---|---|---|---|---|---|
Mean age in years [SD] | 78.9 [6.7] | 78.8 [8.1] | 77.6 [8.7] | 78.5 [7.8] | 0.238 |
Gender, n female [%] | 100 [50.0] | 94 [52.2] | 91 [62.3] | 285 [54.2] | 0.061 |
MMSE score, mean [SD] | 23.1 [1.6] | 17.8 [1.7] | 8.7 [4.5] | 17.3 [6.4] | N/A |
Mean time since diagnosis in years [SD] | 1.8 [2.1] | 2.0 [1.9] | 3.1 [2.2] | 2.2 [2.1] | <0.001 |
Caregiver lives with patient, n [%] | 156 [78.0] | 129 [71.7] | 122 [83.6] | 407 [77.4] | 0.037 |
Caregiver is spouse, n [%] | 144 [72.0] | 113 [62.8] | 98 [67.1] | 355 [67.5] | 0.043b |
Caregiver mean age in years [SD] | 69.4 [11.70] | 66.9 [11.77] | 68.7 [12.21] | 68.3 [11.90] | 0.099 |
Caregiver gender, n female [%] | 129 [64.5] | 120 [66.7] | 76 [52.1] | 325 [61.8] | 0.016 |
AD medication use, n [%] | 0.012 | ||||
No AD medication | 31 [15.5] | 29 [16.1] | 19 [13.1] | 79 [15.0] | − |
Acetylcholinesterase inhibitor monotherapy | 167 [83.5] | 144 [80.0] | 113 [77.9] | 424 [80.8] | − |
Memantine monotherapy | 1 [0.5] | 5 [2.8] | 5 [3.4] | 11 [2.1] | − |
Acetylcholinesterase inhibitor + memantine | 1 [0.5] | 2 [1.1] | 8 [5.5] | 11 [2.1] | − |