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Table 2 Unadjusted and adjusted hazard ratios (HR) of progression to mild cognitive impairment (MCI) and dementia by stable vs. unstable subjective cognitive decline (SCD) in reference to controls (no SCD)

From: Outcomes of stable and unstable patterns of subjective cognitive decline – results from the Leipzig Longitudinal Study of the Aged (LEILA75+)

   Model 1 Model 2 Model 3 Model 4
  HR (95 %-CI) p HR (95 %-CI) p HR (95 %-CI) p HR (95 %-CI) p
SCD Reference: no SCD 1   1   1   1  
  Unstable SCD 0.53 (0.37–0.74) <.001 0.56 (0.39–0.79) <.01 .50 (0.35–0.72) <.001 0.47 (0.33–0.69) <.001
  Stable SCD 1.78 (1.24–2.55) <.01 1.76 (1.20–2.58) <.05 1.55 (1.04–2.32) < .05 1.38 (0.91–2.09) .13
Age    1.01 (1.01–1.02) <.001 1.01 (1.01–1.02) < .001 1.01 (1.00–1.02) <.01
Gender Reference: male   0.95 (0.67–1.34) .76 0.96 (0.68–1.36) .83 0.94 (0.67–1.34) .75
Education Reference: low   1   1   1  
  Middle    1.72 (1.21–2.44) <.01 1.57 (1.09–2.27) <.05 1.61 (1.11–2.33) <.05
  High    1.36 (0.88–2.10) .17 1.34 (0.85–2.11) .20 1.54 (0.96–2.47) .07
Depressive symptoms/CES-D    1.00 (1.00–1.01) .05 1.00 (1.00–1.01) .09
Cognitive functioning/MMSE     0.97 (0.94–0.99) <.05
  1. Abbreviations: CES-D 20-item Center of Epidemiologic Studies Depression Scale, CI confidence interval, HR hazard ratio, MCI mild cognitive impairment, MMSE Mini-Mental State Examination, SCD subjective cognitive decline