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Table 2 Concentration of amino acids and monoamine metabolites in CSF

From: Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity

 

No dementia (n = 39)

Dementia (n = 38)

No delirium

(n = 21)

Delirium

(n = 18)

p-value

No delirium

(n = 3)

Delirium

(n = 35)

p-value

Amino acids

 Alanine, μmol/L

25 (20–36)

27 (19–43)

0.39

17 (16–17)

25 (20–32)

0.128

 Arginine, μmol/L

12 (11–16)

12 (9–17)

0.53

9 (9–9)

12 (9–13)

0.25

 Aspargine, μmol/L

5 (4–6)

6 (3–8)

0.51

3 (3–3)

4 (4–5)

0.07

 Glutamate, μmol/L

0.7 (0.4–1.8)

0.9 (0.6–1.7)

0.44

0.6 (0.3–0.6)

0.5 (0.4–0.8)

0.91

 Glutamine, μmol/L

460 (360–528)

505 (384–588)

0.34

284 (278–284)

385 (321–457)

0.045

 Glycine, μmol/L

28 (24–35)

27 (21–38)

0.51

23 (22–23)

28 (25–36)

0.72

 Isoleucine, μmol/L

5 (3–6)

6 (3–10)

0.11

5 (4–5)

6 (4–7)

0.88

 Leucine, μmol/L

11 (7–15)

12 (9–22)

0.38

12 (9–12)

13 (9–16)

0.98

 Lysine, μmol/L

13 (11–15)

13 (10–17)

0.77

10 (10–10)

12 (10–15)

0.48

 Methionine, μmol/L

3 (2–4)

4 (3–6)

0.030

3 (1–3)

4 (3–5)

0.029

 Phenylalanine, μmol/L

9 (7–13)

14 (9–19)

0.014

6 (6–6)

9 (7–11)

0.021

 Serine, μmol/L

17 (14–18)

15 (10–17)

0.21

13 (13–13)

15 (12–18)

0.92

 Taurine, μmol/L

8 (7–11)

8 (6–10)

0.64

8 (7–8)

7 (5–9)

0.71

 Tryptophan, μmol/L

0.8 (0.6–1.0)

1.1 (0.7–1.5)

0.042

0.6 (0.4–0.6)

0.7 (0.6–0.9)

0.15

 Tyrosine, μmol/L

5 (4–7)

8 (5–11)

0.028

4 (3–4)

5 (4–7)

0.041

 Valine, μmol/L

16 (13–25)

18 (14–31)

0.32

12 (12–12)

15 (12–21)

0.47

Monoamine metabolites

 HVA, nmol/L

170 (102–280)

204 (125–250)

0.42

134 (67–134)

114 (68–179)

0.88

 5HIAA, nmol/L

138 (111–156)

170 (119–261)

0.048

99 (81–99)

104 (68–(140)

0.84

  1. IQR interquartile range, HVA homovanillic acid, 5HIAA 5-hydroxyindoleacetic
  2. Concentration of amino acids and monoamine metabolites in hip fracture patients with and without delirium, stratified by pre-fracture dementia status. All values are median (IQR). P-values were calculated using Mann–Whitney U test. P-values below 0.05 are in bold