Table 2 Comparisons of SaO₂, VO_2max and MWD at Baseline, 12, 30 and 48 weeks, and mixed effect model to test the effect Time, Time*Group and Group

SaO₂ Bl

96.9 (.5)

96.9 (.5)

.395(78)

0.694

0.00 (−.44;.44)

F(2.5;192.4) = 94.370;

p <.001;

η2 = .554

F(2.5;192.4) = 78.769;

p <.001;

η2 = .509

F(1;76) = 135.937;

p <.001;

η2 = .641

SaO₂ 12 W

97.0 (.6)

98.4 (.5)

−11.340(78)

<.001

2.33(1.88;2.78)

SaO₂ 30 W

97.1 (.5)

97.9 (.8)

−5.273(66.5)^a

<.001

1.60(1.16;2.04)

SaO₂ 48 W

97.0 (.6)

97.7 (1.1)

−3.818(60.0)^a

<.001

1.17(.73;1.61)

VO_2max Bl

1.8 (.1)

1.8 (.1)

-.009(78)

0.993

0.00 (−.44;.44)

F(2.5;190.1) = 45.422;

p <.001;

η2 = .374

F(2.5;190.1) = 39.061;

p <.001;

η2 = .339

F(1;76) = 85.529;

p <.001;

η2 = .529

VO_2max 12 W

1.8 (.1)

2.0 (.1)

−7.057(64.2)^a

<.001

2.00(1.56;2.44)

VO_2max 30 W

1.8 (.1)

1.9 (.1)

−4.189(78)

<.001

1.00(.56;1.44)

VO_2max 48 W

1.7 (.1)

1.9 (.1)

−5.645(70.0)^a

<.001

2.00(1.56;2.44)

MWD Bl

687.0 (33.7)

689.7 (33.0)

-.365(78)

0.716

0.08(−.36;.52)

F(2.5;188.9) = 93.137;

p <.001;

η2 = .551

F(2.5;188.9) = 70.772;

p <.001;

η2 = .482

F(1;76) = 148.211;

p <.001;

η2 = .661

MWD 12 W

697.7 (46.7)

861.7 (57.9)

−13.956(74.6)^a

<.001

3.74(3.28;4.20)

MWD 30 W

700.9 (40.6)

796.5 (84.8)

−6.431(56.0)^a

<.001

2.35(1.90;2.80)

MWD 48 W

694.8 (31.3)

782.1 (75.5)

−6.753(52.0)^a

<.001

2.79(2.34;3.24)