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Table 2 Characteristics of subjects according to the klotho G-395A polymorphism (N = 695)

From: The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people

Characteristics Total (N = 695) Men (N = 220) Women (N = 475)
GG genotype (N = 490) GA + AA genotype (N = 205) P GG genotype (N = 161) GA + AA genotype (N = 59) P GG genotype (N = 329) GA + AA genotype (N = 146) P
Age (years) 93.6 ± 3.3 93.2 ± 2.9 0.074 93.4 ± 3.2 93.2 ± 3.0 0.679 93.8 ± 3.4 93.2 ± 2.9 0.073
Women (%) 67.1 71.2 0.292 - - - - - -
BMI (kg/m2) 19.2 ± 3.8 19.4 ± 3.3 0.727 19.6 ± 4.1 20.0 ± 3.1 0.505 19.1 ± 3.6 19.1 ± 3.4 0.952
Smoking habits* 45.0 37.9 0.089 71.2 67.2 0.568 32.1 26.2 0.198
Alcohol habits** 25.5 27.2 0.645 42.1 29.3 0.086 17.4 26.4 0.026
Exercise habits*** 41.2 39.3 0.652 42.0 39.7 0.753 40.7 39.2 0.748
SUA (mmol/L) 318.8 ± 87.5 318.7 ± 89.9 0.998 346.1 ± 81.3 369.3 ± 98.6 0.079 305.5 ± 87.4 298.2 ± 77.5 0.387
MetS (%) 10.8 5.9 0.040 3.7 1.7 0.447 14.3 7.5 0.038
Components of MetS
Abdominal obesity (%) 25.5 26.3 0.819 9.3 5.1 0.310 33.4 34.9 0.750
Hypertriglyceridemia (%) 19.2 11.7 0.017 10.2 5.6 0.233 20.7 12.3 0.029
Low HDL-C (%) 16.1 14.1 0.623 9.9 1.7 0.043 19.2 19.7 0.894
High BP (%) 66.3 49.8 <0.001 62.1 45.8 0.030 68.4 51.4 <0.001
High FPG (%) 13.7 17.6 0.188 20.5 22.0 0.804 10.3 15.8 0.094
  1. Abbreviations: BMI body mass index, BP blood pressure, FPG fasting plasma glucose, HDL-C high density lipoprotein cholesterol, MetS metabolic syndrome, SUA serum uric acid
  2. *Indicates those who were a smoker at the time of the interview
  3. **Indicates those who still drank alcohol at least once a day at the time of the interview
  4. ***Indicates those who still did some physical exercise at least 3 time per week at the time of the interview