Table 4 Relationships between insulin-resistance and inflammatory markers with cognitive impairment
Normal cognitive ageing (n = 801, 51 %) | Mild cognitive impairment (n = 636, 41 %) | Severe cognitive impairment (n = 133, 8 %) | P value* | |
|---|---|---|---|---|
HOMA | ||||
Top Tertile (> = 2.63), n(%) | 221 (32 %) | 186 (33 %) | 53 (46 %) | .01 |
Relative Risk Ratio (95 % CI)a | 1.00 | 1.05 (0.83–1.33) | 1.87 (1.25–2.80)ǁ | |
Relative Risk Ratio (95 % CI)b | 1.00 | 0.92 (0.69–1.22) | 1.58 (0.97–2.58) | |
Interleukin-6 | ||||
Top Tertile (> = 3.8 pg/L), n(%) | 223 (30 %) | 211 (35 %) | 58 (48 %) | <.001 |
Relative Risk Ratio (95 % CI)a | 1.00 | 1.26 (1.00–1.59) | 2.03 (1.37–3.01)ǁ | |
Relative Risk Ratio (95 % CI)b | 1.00 | 1.03 (0.79–1.35) | 1.90 (1.20–3.01)ǁ | |
C-Reactive Protein | ||||
Top Tertile (> = 2.2 mg/L), n(%) | 234 (31 %) | 202 (34 %) | 52 (43 %) | .05 |
Relative Risk Ratio (95 % CI)a | 1.00 | 1.10 (0.88–1.39) | 1.55 (1.05–2.30)§ | |
Relative Risk Ratio (95 % CI)b | 1.00 | 1.00 (0.77–1.30) | 1.40 (0.89–2.21) | |