|
Variable
|
T1: 12 weeks
|
Exercise
|
Control
|
Difference between groups at T0, T1 and T2
|
P-value T2
|
|---|
|
T2: 6 months
| | |
|---|
|
Means (SD)/ Adjusted means (CI)
|
Within group change T1T2
|
Means (SD)/ Adjusted means (CI)
|
Within group change T1T2
|
|---|
|
Berg
|
T0
|
34.3 (14.4)
|
−1.5 (−3.1–0.2)
|
35.3 (13.7)
|
−2.2 * (−4.2--0.3)
|
1.0
| |
|
T1
|
38.4 (36.8–40.1)
|
36.2 (34.7–37.6)
|
2.3
| |
|
T2
|
37.0 (35.0–38.9)
|
33.9 (32.0–35.9)
|
3.0
|
0.031*
|
|
CST
|
T0
|
6.0 (3.1)
|
−0.4 (−0.9–0.3)
|
6.2 (2.9)
|
−0.3 (−1.1–0.3)
|
0.2
| |
|
T1
|
7.1 (6.6–7.7)
|
6.5 (6.0–7.1)
|
0.6
| |
|
T2
|
6.8 (6.2–7.4)
|
6.2 (5.4–6.9)
|
1.7
|
0.175
|
|
NWS
|
T0
|
0.5 (0.2)
|
−0.02 (−0.04–0.02)
|
0.5 (0.2)
|
−0.01 (−0.1–0.03)
|
0
| |
|
T1
|
0.49 (0.46–0.51)
|
0.49 (0.44–0.54)
|
−0.001
| |
|
T2
|
0.47 (0.44–0.51)
|
0.46 (0.43–0.5)
|
0.01
|
0.685
|
|
Barthel
|
T0
|
13.5 (3.5)
|
−0.6 (−1.3–0.1)
|
13.4 (3.6)
|
−0.8 (−1.6–0.03)
|
0.1
| |
|
T1
|
13.7 (13.0–14.3)
|
12.9 (12.3–13.5)
|
0.8
| |
|
T2
|
13.0 (12.3–13.8)
|
12.1 (11.2–12.9)
|
1.0
|
0.082
|
|
MMSE
|
T0
|
15.5 (0.6)
|
−1.0* (−1.9–0.2)
|
15.7 (4.9)
|
−1.4* (−2.4--0.5)
|
0.2
| |
|
T1
|
15.4 (14.5–16.3)
|
15.3 (14.6–16.1)
|
0.1
| |
|
T2
|
14.4 (13.5–15.2)
|
13.9 (12.9–14.9)
|
0.5
|
0.492
|
|
NPI sum
|
T0
|
6.1 (6.1)
|
0.03 (−1.3–1.3)
|
4.8 (4.6)
|
0.7 (−0.8–2.3)
|
1.3
| |
|
T1
|
4.8 (3.7–5.8)
|
5.6 (4.1–7.1)
|
−0.9
| |
|
T2
|
4.8 (3.8–5.8)
|
6.4 (5.1–7.7)
|
−1.6
|
0.059
|
|
Affective
|
T0
|
1.2 (1.5)
|
−0.04 (−03–02)
|
0.8 (1.3)
|
−0.1 (−0.3–0.4)
|
0.4
| |
|
T1
|
0.9 (0.6–1.2)
|
1.0 (0.7–1.4)
|
−0.1
| |
|
T2
|
0.9 (0.6–1.1)
|
1.1 (0.8–1.4)
|
−0.2
|
0.257
|
|
Agitation
|
T0
|
1.7 (2.1)
|
0.04 (−0.5–0.5)
|
1.3 (1.7)
|
0.2 (−0.3–0.8)
|
0.4
| |
|
T1
|
1.3 (0.9–1.7)
|
1.8 (1.3–2.3)
|
−0.5
| |
|
T2
|
1.4 (1.0–1.8)
|
2.0 (1.5–2.5)
|
−0.7
|
0.045*
|
|
Apathy
|
T0
|
0.6 (0.8)
|
0.08 (−0.03–0.3)
|
0.4 (0.7)
|
0.15 (−0.1–0.3)
|
0.2
| |
|
T1
|
0.3 (0.2–0.4)
|
0.4 (0.2–0.6)
|
−0.1
| |
|
T2
|
0.4 (0.3–0.6)
|
0.5 (0.3–0.7)
|
−0.1
|
0.688
|
|
QUALID
|
T0
|
18.4 (6.1)
|
−0.2 (−1.6–1.2)
|
17.7 (5.4)
|
1.1 (−0.2–2.6)
|
0.7
| |
|
T1
|
18.1 (16.8–19.3)
|
17.7 (16.4–19.0)
|
0.4
| |
|
T2
|
17.8 (16.7–19.0)
|
18.8 (17.3–20.2)
|
−0.9
|
0.326
|
|
Cornell Scala
|
T0
|
4.9 (4.8)
|
0.8 (−0.8–2.4)
|
4.9 (4.2)
|
1.4* (0.1–2.6)
|
0
| |
|
T1
|
4.0 (2.6–5.4)
|
3.8 (2.8–4.7)
|
0.2
| |
|
T2
|
4.8 (3.8–5.8)
|
5.1 (4.0–6.3)
|
−03
|
0.668
|
- Results at T0 are given as mean (SD). Results at T1 and T2 are estimated means (95 % confidence interval) or mean difference (95 % confidence interval) derived from the linear mixed model
-
BBS Berg Balance Scale, CST Chair stand test, NWS Normal walking speed, BI Barthel Index, MMSE Mini Mental State Examination, NPI Neuropsychiatric Inventory Questionnaire
- T0 = baseline, T1 = 12 weeks, T2 = 6 months
- *p < 0.05
